自伤与激素水平改变  

Self-injury and changes of hormone level

作　　者：牛耕耘 李超 马家惠 赵明明 刘增训[2] Niu Gengyun;Li Chao;Ma Jiahui;Zhao Mingming;Liu Zengxun(School of Mental Health(Research Institute of Mental Health),Jining Medical University,Jining 272067,China;Shandong Mental Health Center,Jinan 250014,China)

机构地区：[1]济宁医学院精神卫生学院(精神医学研究院),济宁272067 [2]山东省精神卫生中心,济南250014

出　　处：《中华行为医学与脑科学杂志》2022年第8期764-768,共5页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：自伤是一个严重的公共卫生问题,尤其在青少年人群中多见。相关研究表明,自伤并不是某个单一因素所导致的。当前关于自伤的发生机制尚不明确,其诊断缺乏可靠的生物学标志物,且至今也没有针对性的治疗靶点。既往研究认为自伤可能与下丘脑-垂体-肾上腺(hypothalamic pituitary adrenal,HPA)轴、β-内啡肽、阿片类及其他激素有关。下丘脑-垂体-甲状腺(hypothalamic pituitary thyroid,HPT)轴与下丘脑-垂体-性腺(hypothalamic pituitary gonadal,HPG)轴是连接神经与激素的内分泌系统,研究发现伴有其他精神障碍(如重度抑郁、双相情感障碍)的自伤人群表现出了HPT轴、HPG轴多种激素的异常。目前关于自伤与HPT轴、HPG轴的研究数量尚少,即使是针对同类激素的不同研究结果也存在差异,且有部分研究涉及到了自杀企图甚至行为。有研究证实了自伤与自杀有关,拓展了探索自伤与激素相关性的可能性。本研究将综述自伤与激素水平改变之间的关系。Self-injury has become a significant public health problem,especially happens in adolescents.Previous studies have suggested that self-injury is related to numerous factors.At present,the occurrence mechanism of self-injury is still unclear,and there is a lack of reliable biological markers in its diagnosis and therapeutic target so far.Previous studies have suggested that self-injury may be related to hypothalamic pituitary adrenal(HPA)axis,β-endorphins,opioids and other hormones.Hypothalamic pituitary thyroid(HPT)axis and hypothalamic pituitary gonadal(HPG)axis are endocrine systems connecting nerves and hormones.Many studies suggested that various hormones in HPT axis and HPG axis of self-injury patients with other mental disorders(such as major depression and bipolar disorder)were abnormal.At present,there are few studies on the relationship between self-injury and HPT axis and HPG axis.There are differences in results even among studies on the same hormones,and some studies involve suicide attempts and even behaviors.Some studies have confirmed that self-injury is related to suicide,expanding the possibility of exploring the correlation between self-injury and hormones.This study will review the relationship between self-injury and hormonal changes.

关 键 词：自伤 激素 下丘脑-垂体-甲状腺轴 下丘脑-垂体-性腺轴 

分 类 号：R749[医药卫生—神经病学与精神病学]