无功能性垂体腺瘤的治疗及预后研究进展  

Research progress in the treatment and prognosis of non-functioning pituitary adenomas

作　　者：陈宁益(综述) 陈益民(审校) CHEN Ningyi;CHEN Yimin(School of Clinical Medicine,Guizhou Medical University,Guiyang 550004,China;Department of Neurosurgery,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学临床医学院,贵州贵阳550004 [2]贵州医科大学附属医院神经外科,贵州贵阳550004

出　　处：《西部医学》2022年第9期1396-1400,共5页Medical Journal of West China

基　　金：贵州省科技计划项目[黔科合2016支撑(2905)];贵州医科大学2018年度学术新苗培养及创新探索专项项目[黔科合平台人才(2018年)5779-35]。

摘　　要：无功能垂体腺瘤(NFPAs)是常见的鞍区良性肿瘤,发病机制尚不明确,其无过量的垂体前叶激素分泌,且大部分病例属于大腺瘤并可向鞍外侵袭,故症状多由于肿瘤压迫视觉通路、海绵窦、硬脑膜及垂体腺体所致,如视力减退、视野缺损、头痛及垂体前叶功能减退等,长期激素缺乏会导致其他系统并发症,严重危害患者生活质量,甚至增加死亡风险,常需临床干预及长期后续管理。本文就无功能性垂体腺瘤手术、放射、药物治疗及预后的研究进展做一综述,以期为临床诊疗提供借鉴和指导。Non-functioning pituitary adenomas(NFPAs)are common benign tumors in the sellar area without excessive hormone secretion,Its pathogenesis is unclear.Most NFPAs are macroadenomas and can invade outside the sella,so they present with symptoms such as vision loss,visual field defect,headache and hypofunction of the anterior pituitary gland due to the tumor oppressing the visual pathway,cavernous sinus or endocranium and pituitary gland.Long-term hormone deficiency can lead to other system complications,seriously endanger the quality of life of patients,and even increase the risk of death.Clinical intervention and long-term follow-up management are necessary.This article presents a review about the research progress on the surgery,radiation,drug treatment and prognosis of NFPAs in order to provide reference and guidance for clinical treatment.

关 键 词：无功能性垂体腺瘤 经鼻蝶手术 垂体功能减退 立体定向放射 多巴胺受体激动剂 

分 类 号：R736.4[医药卫生—肿瘤]