Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders  

作　　者：Yueting Gu Qiong Bian Yanjun Zhou Qiaoling Huang Jianqing Gao 

机构地区：[1]Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Zhejiang Huanling Pharmaceutical Technology Company,Jinhua 321000,China [3]The Third People’s Hospital of Hangzhou,Hangzhou 310009,China [4]Jiangsu Engineering Research Center for New-type External and Transdermal Preparations,Changzhou 213149,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2022年第3期333-352,共20页亚洲药物制剂科学（英文）

摘　　要：The hair follicle is not only a critical penetration route in percutaneous absorption but also has been recognized to be a target for hair follicle-associated disorders,such as androgenetic alopecia(AGA)and acne vulgaris.Hair follicle-targeting drug delivery systems allow for controlled drug release and enhance therapeutic efficacywithminimal side effects,exerting a promising method for themanagement of hair follicle-associated dysfunctions.Therefore,they have obtained much attention in several fields of research in recent years.This review gives an overviewof potential follicle-targeting drug delivery formulations currently applied based on the particularities of the hair follicles,including a comprehensive assessment of their preclinical and clinical performance.

关 键 词：Follicular drug delivery Androgenetic alopecia Acne vulgaris NANOTECHNOLOGY MICRONEEDLES 

分 类 号：R943[医药卫生—药剂学]