Metal ions-bridged J-aggregation mediated nanoassembly composition for breast cancer phototherapy  

作　　者：Chen Chen Shan Yang Yufei Liu Yue Qiu Jing Yao 

机构地区：[1]State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals,Department of Pharmaceutics,China Pharmaceutical University,Nanjing 211198,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2022年第2期230-240,共11页亚洲药物制剂科学（英文）

基　　金：supported by the “333 Project Talent Training Fund of Jiangsu Province (BRA2017432);the Project of Double-top Class Innovation Team (CPU2018GY14);the Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University (JKGQ201107);the Open Project of Jiangsu Key Laboratory of Druggability of Biopharmaceuticals (JKLDBKF201702)

摘　　要：Recently, the highly ordered J-aggregates of organic dyes with intriguing optical properties have received considerable attention in biomedical applications. Herein, binary metal ions Mn(Ⅱ)/Fe(Ⅲ) are used to induce the formation of indocyanine green(ICG) J-aggregates.Further, the sheet-like J-aggregates are able to act as "carriers" for loading hydrophobic chemotherapeutic gambogic acid(GA), realizing the effect of "killing two birds with one stone" for both treatment and delivery. The as-designed nanoassembly is formed spontaneously in aqueous environment via π-π stacking, electrostatic interaction, and hydrophobic force, exhibiting enhanced photostability of ICG and outstanding reactive oxygen species(ROS) generation ability. Moreover, significant inhibition of tumor growth by the synergetic effect of phototherapy and chemotherapy is verified in a subcutaneous4T1 tumors model. In conclusion, this work not only presents a facile and green approach to manufacture carrier-free nanodrugs, but also establishes a universal platform that has potential application in the co-delivery of near-infrared dye and hydrophobic molecules.

关 键 词：Metal ions J-AGGREGATES Combination therapy 

分 类 号：R737.9[医药卫生—肿瘤]