萝卜硫素提取纯化及其抗癌功能研究进展  

Research Progress in Extraction,Purification and Anticancer Function of Sulforaphane

作　　者：张璇 田明硕 王健[1] 高明坤 高宇航 刘媛[1] 徐东辉[2] 刘广洋 ZHANG Xuan;TIAN Mingshuo;WANG Jian;GAO Mingkun;GAO Yuhang;LIU Yuan;XU Donghui;LIU Guangyang(College of Agriculture and Forestry Science and Technology,Hebei North University,Hebei Key Laboratory of Quality&Safety Analysis-Testing for Agro-Products and Food,Zhangjiakou 075000,China;The Institute of Vegetables and Flowers,Chinese Academy of Agricultural Sciences,Key Laboratory of Vegetables Quality and Safety Control,Laboratory of Quality&Safety Risk Assessment for Vegetable Products(Beijing),Ministry of Agriculture and Rural Affairs of China,Beijing 100081,China;College of Life Sciences and Food Engineering,Hebei University of Engineering,Handan 056038,China)

机构地区：[1]河北北方学院农林科技学院,河北省农产品食品质量安全分析检测重点实验室,河北张家口075000 [2]中国农业科学院蔬菜花卉研究所,农业农村部蔬菜质量安全控制重点实验室,农业农村部蔬菜产品质量安全风险评估实验室(北京),北京100081 [3]河北工程大学生命科学与食品工程学院,河北邯郸056038

出　　处：《食品工业科技》2022年第17期424-434,共11页Science and Technology of Food Industry

基　　金：中国农科院重大科研任务(CAAS-ZDRW202011;CAAS-XTCX2019025);国家现代农业技术产业体系建设专项基金项目(CARS-23-E03);河北省省属高校基本科研业务费项目(JYT2019018);农业农村部蔬菜质量安全控制重点实验室开放课题(KFV-202004-3)。

摘　　要：硫代葡萄糖苷是十字花科蔬菜中一类重要的含硫阴离子亲水性天然产物,其在内源黑芥子酶的催化下,可以水解生成具有抗癌、抗氧化、抑菌等多种功效的活性物质,引起研究者们的广泛关注。萝卜硫素是目前发现的抗癌效果最好、效力最强的一种硫代葡萄糖单体,作为药品或功能食品的有效成分,具有较高的研究价值和广阔的应用前景。本研究概述了萝卜硫素的来源、结构性质、功能活性,系统介绍了其提取工艺、分离纯化方法和抗癌应用等相关研究进展,并对其研究前景进行了探讨与展望,以期为萝卜硫素功能成分的研发和高附加值利用提供研究基础和技术支撑。Glucosinolates are a kind of important sulfur-containing anionic hydrophilic natural products in cruciferous vegetables.Under the catalysis of endogenous myrosinase,glucosinolates can be hydrolyzed to produce active substances with anti-cancer,anti-oxidation,antimicrobial and other effects,which have attracted wide attention of researchers.Sulforaphane is a thioglucose monomer with the best anticancer effect and the strongest efficacy.As an effective component of drugs or functional foods,it has high research value and broad application prospects.In this study,the source,structure,properties,functional activities of sulforaphane are summarized,and its extraction technology,separation and purification methods and anticancer applications are systematically introduced.The research prospect is discussed and anticipated,in order to provide research basis and technical support for the research and development of sulforaphane functional components and high value-added utilization.

关 键 词：萝卜硫素 结构性质 提取方法 分离纯化 抗癌应用 

分 类 号：TS255[轻工技术与工程—农产品加工及贮藏工程] R284[轻工技术与工程—食品科学与工程]