微小RNA在口腔白斑病诊断及治疗中的应用  

Application of MicroRNAs in Diagnosis and Treatment of Oral Leukoplakia

作　　者：刘佳鑫 但红霞 LIU Jiaxin;DAN Hongxia(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,口腔黏膜病国家临床重点专科,中国医学科学院口腔黏膜癌变与防治创新单元,四川大学华西口腔医院,四川成都610041

出　　处：《口腔医学研究》2022年第9期807-810,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:82071125,U19A2005);四川省科技计划项目(编号:2020YFS0044,2020YFSY009);四川大学华西口腔医院探索与研发项目(编号:LCYJ2019-11)。

摘　　要：微小RNA是一种内源性、高度保守的非编码RNA,参与机体多种生物活动,并且和多种癌症的发生和发展密切相关。近期的研究发现微小RNA具有作为口腔白斑病癌变风险预测的分子标记物和治疗靶点的潜力。本文就微小RNA在口腔白斑病临床应用的研究进展做一综述。MicroRNA(miRNA) is an endogenous highly conserved non-coding RNA, which is involved in various biological activities of the body, and is closely related to the development of a variety of cancers. Recent studies have shown the potential of miRNAs as a molecular marker for malignant transformation of oral leukoplakia and therapeutic target of oral leukoplakia. In this study, the application of miRNAs in the diagnosis and treatment of oral leukoplakia was reviewed.

关 键 词：微小RNA 口腔白斑病 恶性转化 

分 类 号：R781.5[医药卫生—口腔医学]