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作 者:王文惠 高琛 崔亮亮 王彬 李贵玉[3] 张继甫 赵红琼 王金泉[1] 李康[4] 郝智慧 WANG Wen-hui;GAO Chen;CUI Liang-liang;WANG Bin;LI Gui-yu;ZHANG Ji-fu;ZHAO Hong-qiong;WANG Jin-quan;LI Kang;HAO Zhi-hui(College of Veterinary Medicine,Xinjiang Agricultural University,Urumqi 830052,China;Chinese Veterinary Medicine Innovation Center,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Chengdu Kehongda Technology Co.Ltd.,Chengdu 611435,China;Agricultural Biopharmaceutical Laboratory,Qingdao Agricultural University,Qingdao 266109,China)
机构地区:[1]新疆农业大学动物医学学院,新疆乌鲁木齐830052 [2]中国农业大学动物医学院中兽医药创新中心,北京海淀100193 [3]成都科宏达科技有限公司,四川成都611435 [4]青岛农业大学农用生物制药实验室,山东青岛266109
出 处:《中国兽医杂志》2022年第7期67-71,77,共6页Chinese Journal of Veterinary Medicine
基 金:山东省“外专双百计划”团队项目(WAT2017010);中国农业大学“人才培育发展支持计划”项目。
摘 要:为了明确复方癸甲氯铵溶液对大肠埃希菌(E.coli)、金黄色葡萄球菌(S.aureus)的消毒效果,本试验采用悬液定性杀菌试验、悬液定量杀菌试验、使用液稳定性试验和金属腐蚀性试验进行观察和评估。结果显示,复方癸甲氯铵溶液对大肠埃希菌、金黄色葡萄球菌的最低有效杀菌浓度分别为1∶12800和1∶25600,该浓度下杀菌最快有效时间均为10 min;复方癸甲氯铵溶液对大肠埃希菌、金黄色葡萄球菌作用2.5 min,杀菌率可达100%,杀灭对数值≥5;在第0~3天内,随时间的延长复方癸甲氯铵溶液pH有下降趋势,且消毒效果稳定,可满足杀菌要求。复方癸甲氯铵溶液对不锈钢和铝基本无腐蚀性,对碳钢和铜有轻度腐蚀性。结果表明,复方癸甲氯铵溶液在较低浓度条件下即能快速有效杀灭细菌,且稳定性好、腐蚀性小。本试验对复方癸甲氯铵溶液的临床应用具有指导意义。This study evaluated the disinfection effect of compound didecyl dimethyl ammonium chloride solution on Escherichia coli and Staphylococcus aureus by using suspension qualitative sterilization test,suspension quantitative sterilization test,working liquid stability test and metal corrosion test.The results showed that the minimum effective bactericidal concentration of compound didecyl dimethyl ammonium chloride solution against E.coli and S.aureus were 1∶12800 and 1∶25600,respectively,and the fastest effective time for sterilization at this concentration was 10 min.Application of compound didecyl dimethyl ammonium chloride solution for 2.5 min was sufficient to completely kill E.coli and S.aureus,with the killing logarithm value≥5.Within 3 days,compound didecyl dimethyl ammonium chloride solution displayed a downward trend in pH with time,and its disinfection effect remained stable,and met sterilization requirements.Compound didecyl dimethyl ammonium chloride solution was basically non-corrosive to stainless steel and aluminum,and slightly corrosive to carbon steel and copper.Thus,compound didecyl dimethyl ammonium chloride solution is capable of quickly and effectively killing bacteria under low concentration conditions,and has good stability and low corrosion,it has great potential for clinical utility.
关 键 词:复方癸甲氯铵溶液 杀菌 消毒效果 大肠埃希菌 金黄色葡萄球菌
分 类 号:S859.79[农业科学—临床兽医学]
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