氢吗啡酮治疗癌性骨痛临床疗效及对血清TNF-α和IL-6的影响  

Clinical effect of hydromorphone on the treatment of bone cancer pain and the effects on serum level of TNF-αand IL-6

作　　者：郭艳汝 任晓娟 姬骁亮 袁媛 刘志静 陈英 马婧 GUO Yanru;REN Xiaojuan;JI Xiaoliang;YUAN Yuan;LIU Zhijing;CHEN Ying;MA Jing(The Department of Pain Management(Palliative Care),Cangzhou People's Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市人民医院疼痛(安宁疗护)科,沧州061000

出　　处：《中国疼痛医学杂志》2022年第8期608-613,共6页Chinese Journal of Pain Medicine

基　　金：2022年度河北省医学科学研究课题计划(20220326)。

摘　　要：目的:探讨盐酸氢吗啡酮注射液皮下镇痛泵治疗中、重度癌性骨痛的镇痛效果,以及对血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(interleukin-6,IL-6)浓度的影响。方法:采用回顾性研究的方法,选取2020年1月至2021年3月采用盐酸氢吗啡酮注射液皮下镇痛泵治疗癌性骨痛病人57例,采用疼痛数字评分法(numerical rating scale,NRS)评分,4~6分为中度癌性骨痛组(M组)26例,7~10分为重度癌性骨痛组(S组)31例。收集两组病人资料并比较两组治疗前后镇痛效果及血清TNF-α和IL-6浓度变化。结果:经盐酸氢吗啡酮注射液皮下镇痛泵治疗后两组病人疼痛均明显缓解(P<0.05),血清TNF-α和IL-6浓度较治疗前下降(P<0.05)。结论:盐酸氢吗啡酮注射液皮下镇痛泵治疗中、重度癌性骨痛效果较好,且两组病人治疗后血清TNF-α及IL-6浓度均降低。Objective:To investigate the analgesic effect of hydromorphone hydrochloride injection with subcutaneous analgesic pump in the treatment of moderate and severe bone cancer pain and its effect on serum tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)concentrations.Methods:A retrospective study was carried out with 57 cases of bone cancer pain treated with hydromorphone hydrochloride injection subcutaneous analgesic pump from January 2020 to March 2021.Patients with numerical rating scale(NRS)4-6 scores were considered as moderate bone cancer pain group(group M)(26 cases),and patients with NRS 7-10 scores were considered as severe bone cancer pain group(group S)(31 cases).The data of the two groups were collected.The analgesic effects and the changes of serum TNF-αand IL-6 concentrations were compared between the two groups before and after treatment.Results:The pain of the two groups was significantly relieved after treatment with hydromorphone hydrochloride injection subcutaneous analgesic pump(P<0.05),and the serum TNF-αand IL-6 concentrations were decreased compared with those before treatment(P<0.05).Conclusion:Hydromorphone hydrochloride injection with subcutaneous analgesic pump is effective in treating moderate and severe bone cancer pain,and the serum TNF-αand IL-6 concentrations of the two groups of patients were decreased after treatment.

关 键 词：盐酸氢吗啡酮注射液 病人自控镇痛 癌性骨痛 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R730.5[医药卫生—肿瘤]