血清Cys-C、α1-MG联合检测在早期肝肾综合征诊断中的意义  

Significance of Combined Detection of Serum Cys-C andα1-MG in Diagnosis of Early Hepatorenal Syndrome

作　　者：叶亮 李运泽 彭继承 龙颖[1] 屈茵萍 蔡怀阳 YE Liang;LI Yun-ze;PENG Ji-cheng;LONG Ying;QU Yin-ping;CAI Huai-yang(Department of Gastroenterology,Affiliated Liuzhou People's Hospital of Guangxi Medical University,Liuzhou 545000,Guangxi,China)

机构地区：[1]广西医科大学附属柳州市人民医院消化内科,广西柳州545000

出　　处：《医学信息》2022年第16期67-69,共3页Journal of Medical Information

基　　金：广西壮族自治区卫生厅计划课题(编号:Z2014543)。

摘　　要：目的探讨胱抑素C(Cys-C)、α1微球蛋白(α1-MG)在诊断早期肝肾综合征中的价值及意义。方法选取2018年3月-2021年5月我院收治的肝硬化失代偿患者40例设为肝硬化失代偿组,肝肾综合征患者40例设为肝肾综合征组。比较两组Cys-C、α1-MG水平,采用受试者工作特征(ROC)曲线分析Cys-C、α1-MG两者单独及联合诊断肝肾综合征的效能。结果肝肾综合征组Cys-C、α1-MG水平高于肝硬化失代偿组,差异有统计学意义(P<0.05)。ROC曲线分析显示,Cys-C+α1-MG诊断肝肾综合征的AUC高于Cys-C、α1-MG单独诊断,且联合诊断的敏感性及阴性预测值高于Cys-C、α1-MG单独诊断。结论Cys-C、α1-MG联合诊断肝肾综合征的预测价值高于单一指标,可作为肝肾综合征早期诊断的重要指标之一。Objective To investigate the value and significance of cystatin C(Cys-C)andα1-microglobulin(α1-MG)in the diagnosis of early hepatorenal syndrome.Methods Forty patients with decompensated cirrhosis admitted to our hospital from March 2018 to May 2021 were selected as decompensated cirrhosis group,and 40 patients with hepatorenal syndrome were selected as hepatorenal syndrome group.The levels of Cys-C andα1-MG were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of Cys-C andα1-MG alone and in combination in the diagnosis of hepatorenal syndrome.Results The levels of Cys-C andα1-MG in hepatorenal syndrome group were higher than those in decompensated cirrhosis group(P<0.05).ROC curve analysis showed that the AUC of Cys-C+α1-MG in the diagnosis of hepatorenal syndrome was higher than that of Cys-C andα1-MG alone,and the sensitivity and negative predictive value of combined diagnosis were higher than those of Cys-C andα1-MG alone.Conclusion The predictive value of Cys-C andα1-MG combined diagnosis of hepatorenal syndrome is higher than that of single index,which can be used as one of the important indexes for early diagnosis of hepatorenal syndrome.

关 键 词：肝肾综合征 胱抑素C Α1微球蛋白 

分 类 号：R575[医药卫生—消化系统]