依达拉奉注射液联合阿替普酶静脉溶栓对急性缺血性脑卒中患者脑血管血流动力学及Ox-LDL、IMA水平的影响  

Effects of edaravone injection combined with alteplase intravenous thrombolysis on cerebrovascular hemodynamics and Ox-LDL,IMA levels in patients with acute ischemic stroke

作　　者：谭永峰 班玉霞 TAN Yongfeng;BAN Yuxia(the People's Hospital of Ganquan County,Yan'an 716100;Yan'an People's Hospital,Yan'an 716000,China)

机构地区：[1]甘泉县人民医院,陕西延安716100 [2]延安市人民医院,陕西延安716000

出　　处：《临床医学研究与实践》2022年第27期67-70,共4页Clinical Research and Practice

摘　　要：目的探讨依达拉奉注射液联合阿替普酶静脉溶栓对急性缺血性脑卒中(AIS)患者脑血管血流动力学及氧化型低密度脂蛋白(Ox-LDL)、缺血修饰清蛋白(IMA)水平的影响。方法选取2018年11月至2020年12月我院收治的92例AIS患者作为研究对象,以抽签法将其分为对照组和观察组,各46例。对照组予以常规治疗结合阿替普酶静脉溶栓,观察组在对照组治疗方案基础上施加依达拉奉注射液。比较两组的脑血管血流动力学指标[血流速度的最小值(V_(min))、动态阻抗(DR)、脉搏波波速(Wv)、外周阻力(R)]、Ox-LDL、IMA水平、神经功能缺损程度及凝血功能指标[血栓调节蛋白(TM)、凝血酶抗凝酶复合物(TAT)、组织型纤溶酶原激活剂-抑制剂复合物(t-PAIC)]。结果治疗后,两组的V_(min)、DR均高于治疗前,Wv、R均低于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的Ox-LDL、IMA水平均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后7、14 d,观察组的美国国立卫生研究院卒中量表(NIHSS)评分均低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的TM、t-PAIC水平均低于治疗前,TAT水平均高于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。结论依达拉奉注射液联合阿替普酶静脉溶栓治疗AIS不仅可改善脑血管血流动力学及凝血功能,调节机体Ox-LDL、IMA水平,还可促进神经功能恢复,值得临床推广应用。Objective To investigate the effects of edaravone injection combined with alteplase intravenous thrombolysis on cerebrovascular hemodynamics and oxidized low density lipoprotein(Ox-LDL),ischemia modified albumin(IMA)in patients with acute ischemic stroke(AIS).Methods A total of 92 patients with AIS admitted in our hospital from November 2018 to December 2020 were selected as the research objects,and the patients were divided into control group and observation group by drawing lots,with 46 cases in each group.The control group was given routine treatment combined with alteplase intravenous thrombolysis,and the observation group was given edaravone injection on the basis of the treatment scheme of the control group.The cerebrovascular hemodynamic indexes[minimum value of blood flow velocity(V_(min)),dynamic resistance(DR),wave velocity(Wv),resistance(R)],Ox-LDL,IMA levels,nerve function defect degree and coagulation function indexes[thrombomodulin(TM),thrombin-antithrombin complex(TAT),tissue plaminogen antivator inhibitor complex(t-PAIC)]were compared between the two groups.Results After treatment,the V_(min) and DR in both groups were higher than those before treatment,the Wv and R were lower than those before treatment,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of Ox-LDL and IMA in the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At 7 and 14 d after treatment,the National Institutes of Health Stroke Scale(NIHSS)score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of TM and t-PAIC in both groups were lower than those before treatment,the level of TAT was higher than that before treatment,those in the observation group were better than the control group,and the differenc

关 键 词：依达拉奉注射液 阿替普酶 静脉溶栓 急性缺血性脑卒中 脑血管血流动力学 氧化型低密度脂蛋白 缺血修饰清蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]