颅内动脉瘤的成因及破裂机制研究进展  

Research progress on the causes and rupture mechanism of intracranial aneurysms

作　　者：张根 荆国杰[2] 祝刚[3] ZHANG Gen;JING Guojie;ZHU Gang(The Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,524000,China;Huizhou First People's Hospital,Huizhou,Guangdong,516000,China;Huizhou Central People's Hospital,Huizhou,Guangdong,516000,China)

机构地区：[1]广东医科大学,广东湛江524000 [2]惠州市第一人民医院,广东惠州516000 [3]惠州市中心人民医院,广东惠州516000

出　　处：《当代医学》2022年第24期192-194,共3页Contemporary Medicine

摘　　要：在过去的几十年中,颅内动脉瘤(IA)发病和破裂的相关机制一直是研究的热点。IA的特征是血管壁内部弹性纤维和基质破坏导致动脉管壁病理性扩张的病理性结构改变。由动脉瘤破裂导致的蛛网膜下腔出血(SAH)患者中35%出现不良预后。本文旨在对IA形成和破裂的炎症途径、基因和危险因素进行综述。In the past few decades,the related mechanism of the onset and rupture of Intracranial aneurysms(IA)has been hot research direction.IA is characterized by pathological structural changes in the arterial wall caused by the destruction of elastic fibers and matrix inside the vessel wall.Up to 35%of patients with subarachnoid hemorrhage caused by aneurysm rupture have a poor prognosis.This review aims to summarize the inflammatory pathways,genes,and risk factors of IA formation and rupture.

关 键 词：动脉瘤 脑出血 发病机制 破裂 研究进展 

分 类 号：R739.41[医药卫生—肿瘤]