抗菌多肽联合甲硝唑治疗慢性牙周炎的效果及对龈下菌群的影响  

Effects of antimicrobial peptides combined with metronidazole on chronic periodontitis and its effect on subgingival flora

作　　者：王翠英 李丽 邢红艳 刘月强 冯江洁 Wang Cuiying;Li Li;Xing Hongyan;Liu Yueqiang;Feng Jiangjie(Department of Stomatology,the Second People’s Hospital of Xinzhou,Xinzhou 034100,China)

机构地区：[1]忻州市第二人民医院口腔科,忻州034100

出　　处：《中国实用医刊》2022年第13期88-91,共4页Chinese Journal of Practical Medicine

摘　　要：目的观察抗菌多肽联合甲硝唑治疗慢性牙周炎的临床效果及对其龈下主要菌群的影响。方法抽取2019年10月至2021年11月忻州市第二人民医院口腔科收治的慢性牙周炎患者60例,按照随机数字表法分为观察组与对照组,每组30例。对照组给予甲硝唑治疗,观察组在对照组治疗基础上给予抗菌多肽联合治疗。比较两组治疗效果、牙周状态(牙周袋深度、菌斑指数及牙龈指数)、龈下主要菌群占比及治疗后不良反应发生情况。结果观察组总有效率(96.67%,29/30)高于对照组(76.67%,23/30),P<0.05。治疗后,观察组牙周袋深度、菌斑指数及牙龈指数均小于对照组(P均<0.05)。治疗后,观察组牙龈卟啉单胞菌、伴放线放线杆菌在牙周细菌总量中的占比[(0.15±0.02)%、(0.011±0.002)%]均低于对照组[(0.20±0.03)%、(0.014±0.002)%],P均<0.05。治疗后,观察组不良反应发生率(16.67%,5/30)与对照组(10.00%,3/30)比较差异未见统计学意义(P>0.05)。结论抗菌多肽联合甲硝唑治疗慢性牙周炎的效果较好,患者经治疗后牙周状态改善,龈下主要致病菌群占比降低,且联合用药安全性较高。Objective To observe the clinical effect of antibacterial peptides combined with metronidazole in the treatment of chronic periodontitis and its influence on the main subgingival flora.Methods Sixty patients with chronic periodontitis treated in the Department of Stomatology in the Second People’s Hospital of Xinzhou from October 2019 to November 2021 were selected,and they were divided into observation group and control group by random number table method,with 30 cases in each group.Patients in the control group were treated with metronidazole,while patients in the observation group were treated with antibacterial peptides based on the treatment of the control group.The treatment effect,periodontal status(periodontal pocket depth,plaque index and gingival index),proportion of subgingival microflora and the risk of adverse reactions after treatment were compared between the two groups.Results The total effective rate of the observation group(96.67%,29/30)was higher than that of control group(76.67%,23/30),P<0.05.After treatment,the periodontal pocket depth,plaque index and gingival index of the observation group were lower than those of control group(all P<0.05).After treatment,the proportions of porphyromonas gingivalis and Actinobacillus actinobacillus concomitant in periodontal bacteria in the observation group were(0.15±0.02)%and(0.011±0.002)%,respectively,lower than the(0.20±0.03)%and(0.014±0.002)%in the control group(all P<0.05).There was no difference in adverse reactions between the observation group(16.67%,5/30)and the control group(10.00%,3/30),P>0.05.Conclusions Antibacterial peptides combined with metronidazole in the treatment of chronic periodontitis has a good effect,the periodontal status of patients can be improved after treatment,and the proportion of subgingival pathogenic bacteria groups can be decreased,and the combined drug safety is high.

关 键 词：慢性牙周炎 抗菌多肽 甲硝唑 牙周状态 龈下菌群 

分 类 号：R781.42[医药卫生—口腔医学]