炎症性肠病患者骨质流失的机制和治疗前景  

Mechanism and Treatment Prospect of Bone Loss in Patients With Inflammatory Bowel Disease

作　　者：冉艳 米琛[1] 厉英超[1] RAN Yan;MI Chen;LI Yingchao(Department of Gastroenterology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061;The Second Department of Gastroenterology,Shaanxi Provincial People’s Hospital,Xi’an)

机构地区：[1]西安交通大学第一附属医院消化内科,710061 [2]陕西省人民医院消化内二科

出　　处：《胃肠病学》2021年第10期631-635,共5页Chinese Journal of Gastroenterology

基　　金：陕西省重点研发国际科技合作计划项目(2019KW-036)。

摘　　要：炎症性肠病(IBD)已逐渐被认为是一种全身性疾病,可影响许多肠外器官或组织,引起多种肠外表现或肠外并发症。骨质流失是IBD的一种常见肠外并发症,IBD患者发生骨量减少、骨质疏松以及骨折的风险均较健康人群增加。IBD患者发生骨质流失的机制包括钙和维生素D缺乏、免疫炎症、肠道菌群失调、内分泌激素和药物影响等。治疗方面除调整生活方式、营养治疗和抗骨质疏松药物外,免疫抑制剂、生物制剂、益生菌以及粪菌移植等手段有望成为IBD患者骨质流失的有效治疗措施。本文就IBD患者骨质流失的机制和治疗前景作一综述。Inflammatory bowel disease(IBD)has been considered gradually as a systemic disease that could affect many extra-intestinal organs or tissues and cause a variety of extra-intestinal manifestations or complications.Bone loss is one of the common extra-intestinal complications of IBD.IBD patients have an increased risk of osteopenia,osteoporosis and fracture than healthy people.The mechanisms of bone loss in IBD patients include deficiency of calcium and vitamin D,immune,inflammation,dysbiosis of gut microbiota,endocrine hormone,and drug effects.In addition to life style adjustment,nutritional therapy and anti-osteoporosis drugs,immunosuppressant,biological agents,probiotics and fecal microbiota transplantation might be expected to become effective treatments for bone loss in IBD patients.This article reviewed the mechanism and treatment prospect of bone loss in patients with IBD.

关 键 词：炎症性肠病 骨质流失 免疫 炎症 肠道菌群 肠-骨轴 治疗 

分 类 号：R574[医药卫生—消化系统]