胎儿型肺腺癌的研究进展  

Research progress of fetal lung adenocarcinoma

作　　者：周瑞婷 李文新[1] 何桂媛 黄婷苑(综述) 曾凡军(审校)[1] Zhou Ruiting;Li Wenxin;He Guiyuan;Huang Tingyuan;Zeng Fanjun(Department of Respiratory Medicine,Yichang Central People's Hospital,Sichuan Province,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院/宜昌市中心人民医院呼吸内科,湖北宜昌443003

出　　处：《疑难病杂志》2022年第9期985-988,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：宜昌市医疗卫生科技项目(A20-2-003)。

摘　　要：胎儿型肺腺癌(FLAC)是一种罕见的肺部肿瘤,占肺癌的0.1%~0.5%,因其病理学表现类似胎儿肺而得名。根据其组织病理学和临床特征的差异,FLAC被分为低级别(L-FLAC)和高级别(H-FLAC)2种类型,二者最显著的差异在于桑葚体的形成及β-catenin、P53的表达特点。近年来,存在于FLAC中新的基因突变的发现使得其定义及分型更具争议,同时也为FLAC的诊断和治疗开辟了新路径。文章就FLAC的定义演变、组织形态学、免疫组化、分子遗传学、临床特征、治疗及预后等方面进行综述,探讨其组织起源和可能的分子机制。Fetal lung adenocarcinoma(FLAC)is a rare lung tumor,accounting for 0.1%to 0.5%of lung cancers,so named because its pathological appearance resembles fetal lung.According to their differences in histopathological and clinical features,FLAC is divided into two types,low-grade(L-FLAC)and high-grade(H-FLAC),the most notable differences between the two are the formation of mulberries and the expression ofβ-catenin and P53 Features.In recent years,the discovery of new gene mutations in FLAC has made its definition and classification more controversial,and also opened up a new path for the diagnosis and treatment of FLAC.This article reviews the evolution of the definition of FLAC,histomorphology,immunohistochemistry,molecular genetics,clinical features,treatment and prognosis,and discusses its tissue origin and possible molecular mechanisms.

关 键 词：胎儿型肺腺癌 低级别胎儿型肺腺癌 高级别胎儿型肺腺癌 肺母细胞瘤 诊断 治疗 

分 类 号：R734.2[医药卫生—肿瘤]