胃癌合并肌少症的研究进展  

Research progress of gastric cancer with concomitant sarcopenia

作　　者：肖海燕 刘婷[2,3] 李岱[1,2] 唐密密 XIAO Haiyan;LIU Ting;LI Dai;TANG Mimi(Phase I Clinical Trial Center,Xiangya Hospital,Central South University,Changsha 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院Ⅰ期临床研究中心,湖南长沙410008 [2]中南大学湘雅医院国家老年疾病临床医学研究中心,湖南长沙410008 [3]中南大学湘雅医院药学部,湖南长沙410008

出　　处：《中国普通外科杂志》2022年第8期1121-1128,共8页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81803233);中国博士后科学基金第69批面上基金资助项目(2021M693561)。

摘　　要：肌少症是与年龄相关、由骨骼肌质量和功能丧失引起的临床综合征,主要诱因包括运动缺乏、神经肌肉功能减弱、增龄相关激素变化以及炎性细胞因子水平升高等。胃癌是我国最常见的消化道肿瘤之一,其发病率和病死率在癌症中分别位居第二、三位,严重威胁人们的健康。多项研究表明,胃癌合并肌少症可显著影响患者的术后状态及生存期,在预测胃癌预后方面有重要意义。并且,治疗胃癌的部分药物以及化疗会导致化疗相关性肌少症,对胃癌患者治疗的结局产生负面影响。近年来,肌少症对胃癌的影响日益受到关注。笔者就肌少症发病机制、化疗相关性肌少症、肌少症预测胃癌预后的意义、胃癌合并肌少症治疗和预防予以综述,以期为胃癌患者精准治疗方案的制定提供新的思路。Sarcopenia is an age-related clinical syndrome caused by loss of skeletal muscle mass and function.The main causes include lack of exercise,weakened neuromuscular function,age-related hormonal changes,and increased levels of inflammatory cytokines.Gastric cancer is one of the most common digestive tract tumors in China,and ranks the second in morbidity and the third in mortality among all cancers,which seriously threatens people's health.A number of studies have shown that gastric cancer with sarcopenia can significantly affect the postoperative state and survival of patients,which is of great significance in predicting the prognosis of gastric cancer.In addition,some drugs and chemotherapy for gastric cancer can lead to chemotherapy-related sarcopenia,which has a negative influence on the treatment outcome of gastric cancer patients.In recent years,the influence of sarcopenia on gastric cancer has attracted increasing attention.Here,the authors address the pathogenesis of sarcopenia,chemotherapy-related sarcopenia,the significance of sarcopenia in predicting the prognosis of gastric cancer,and the treatment and prevention of gastric cancer complicated with concomitant sarcopenia,so as to provide new avenues for development of precise treatment protocols for gastric cancer patients.

关 键 词：胃肿瘤 肌减少症 老年医学 预后 综述 

分 类 号：R735.2[医药卫生—肿瘤]