早期应用丁苯酞联合氯吡格雷治疗急性期脑梗死的疗效与安全性  

Efficacy and safety of butylphthalide combined with clopidogrel in the early treatment of acute cerebral infarction

作　　者：张强 贾鹏[2] ZHANG Qiang;JIA Peng(Kunshan Zongrenqing Memorial Hospital,Jiangsu Province,Suzhou 215300,China;不详)

机构地区：[1]昆山宗仁卿纪念医院,江苏省苏州市215300 [2]南京医科大学第二附属医院神经内科,南京市210011

出　　处：《临床合理用药杂志》2022年第22期16-18,22,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察早期应用注射丁苯酞联合氯吡格雷治疗急性脑梗死的疗效与安全性。方法选取2018年1月1日—2020年12月30日昆山宗仁卿纪念医院收治的急性脑梗死患者62例,基于随机抽签规则均分为观察组与对照组,每组31例。对照组予常规方法治疗,观察组则在对照组的基础上予丁苯酞联合氯吡格雷治疗,2组患者均治疗20 d。比较2组患者治疗前后神经功能、临床疗效及不良反应。结果治疗20 d后,2组患者的美国国立卫生院神经功能缺损量表(NIHSS)评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.01);观察组患者治疗总有效率为96.77%,高于对照组的80.65%,差异有统计学意义(χ^(2)=4.026,P=0.045)。观察组患者不良反应总发生率为0,低于对照组的12.90%(4/31),差异有统计学意义(χ^(2)=4.276,P=0.039)。结论早期应用丁苯酞联合氯吡格雷治疗急性期脑梗死不仅可提高治疗效果,还可改善神经功能,安全可靠,值得应用。Objective To observe the effect and safety of early application of injection of butylphthalide combined with clopidogrel in the treatment of acute cerebral infarction.Methods A total of 62 patients with acute cerebral infarction admitted to Kunshan Zongrenqing Memorial Hospital from January 1,2018 to December 30,2020 were selected and divided into observation group and control group based on random drawing rules,31 patients in each group.The control group was treated with conventional methods,while the observation group was treated with butylphthalide combined with clopidogrel on the basis of the control group,both groups were treated for 20 days.The neurological function,clinical efficacy and adverse reactions of 2 groups were compared before and after treatment.Results After 20 days of treatment,the scores of National Institutes of Health Neurological Deficit Scale(NIHSS)in 2 groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.01).The total effective rate in observation group was 96.77%,significantly higher than 80.65%in control group,the difference was statistically significant(χ^(2)=4.026,P=0.045).The total incidence of adverse reactions in observation group was 0,which was significantly lower than 12.90%(4/31)in control group,the difference was statistically significant(χ^(2)=4.276,P=0.039).Conclusion Early application of butylphthalide combined with clopidogrel in the treatment of acute cerebral infarction can not only improve the therapeutic effect,but also improve the neurological function,safe and reliable,worthy of application.

关 键 词：急性脑梗死 丁苯酞 氯吡格雷 早期应用 临床疗效 神经功能 不良反应 

分 类 号：R743.33[医药卫生—神经病学与精神病学]