基于肠道菌群介导的脑肠轴理论探讨针灸治疗轻度认知功能障碍思路  

Discussion on Acupuncture and Moxibustion for Mild Cognitive Impairment Based on Theory of Brain-Gut Axis Mediated by Intestinal Flora

作　　者：胡芬 林冕 诸剑芳[2] HU Fen;LIN Mian;ZHU Jianfang

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江医院针灸科,浙江杭州310013

出　　处：《新中医》2022年第16期151-155,共5页New Chinese Medicine

基　　金：2020年度浙江省中医药科学研究基金项目(2020ZA002)。

摘　　要：以肠道菌群作为认识的切入点,基于肠道菌群介导的脑肠轴理论探讨分析针灸治疗轻度认知功能障碍的思路。分析总结认为,在现代医学上,肠道菌群能够通过脑肠轴这一途径进一步影响中枢神经系统;而中医学认为,脑与肠在脏腑生理功能上互相关联,在病理上互相影响。基于肠道菌群介导的脑肠轴与轻度认知功能障碍密切相关,脑肠轴对轻度认知功能障碍患者的认知功能有重要的影响。针灸可通过调节肠道菌群、调节脑肠轴、有效降低细胞外β-淀粉样蛋白的沉积,最终实现从肠治脑治疗轻度认知功能障碍。因此,在针灸治疗轻度认知功能障碍时,可重视手阳明大肠经、手太阳小肠经、足阳明胃经以及腹部腧穴的应用以达到良效。Starting from the perspective of intestinal flora,this paper discusses and analyzes the idea of treating mild cognitive impairment with the therapy of acupuncture and moxibustion based on the theory of brain-gut axis mediated by intestinal flora.After analysis,it can be concluded that modern medicine believes that intestinal flora can further affect the central nervous system through the brain-gut axis;in Chinese medicine,the brain and the intestine are interconnected in the physiological function of the zangfu organs and interact with each other in pathology.Because the brain-gut axis mediated by intestinal flora is closely related to mild cognitive impairment,it has an important influence on cognitive function in patients with mild cognitive impairment.The therapy of acupuncture and moxibustion can effectively reduce the deposition of extracellular β-amyloid protein by regulating the intestinal flora and brain-gut axis and ultimately achieve the treatment of mild cognitive impairment by treating the brain disease from the intestine.Therefore,in the treatment of mild cognitive impairment with the therapy of acupuncture and moxibustion,attention should be paid to the application of the large intestine meridian,small intestine meridian,stomach meridian and abdominal points,and by doing so,good results can be achieved.

关 键 词：轻度认知功能障碍 肠道菌群 脑肠轴 针灸 

分 类 号：R749.16[医药卫生—神经病学与精神病学]