肝癌微环境时空异质性与个体化免疫治疗  

Spatiotemporal Heterogeneity of Liver Cancer Microenvironment and Personalized Immunotherapy

作　　者：成怡斐 高强 CHENG Yifei;GAO Qiang(Department of Liver Surgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院肝外科,复旦大学肝癌研究所,上海200032

出　　处：《中国细胞生物学学报》2022年第4期559-571,共13页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82130077,81961128025);上海市优秀学科带头人计划(批准号:19XD1420700)资助的课题。

摘　　要：肿瘤免疫微环境(tumor immune microenvironment,TIME)是一个高度复杂的生态系统,肿瘤细胞与免疫细胞在时间、空间维度动态互作,产生时空异质性(spatiotemporal heterogeneity)。值得注意:肝癌免疫微环境异质性与临床表型显著相关;抗原呈递、趋化因子、免疫代谢等相关机制参与了免疫微环境异质性的时空调控。未来,随着研究工具不断进步、对时空异质性解析逐渐深入,基于个体免疫微环境动态特征,建立个体化免疫治疗(personalized immunotherapy)新策略,将使更多肿瘤患者获益。TIME(tumor immune microenvironment)is a highly organized ecosystem made of cancer cells and surrounding immune cells.These two components communicate and interact with each other at spatial and temporal levels,resulting in spatiotemporal heterogeneity.It’s noteworthy that spatiotemporal TIME heterogeneity closely correlates with clinically relevant neoplastic phenotypes.And antigen presentation,chemokine programs,and immune metabolism play key roles in the regulation of spatial and temporal TIME heterogeneity.With the application of novel research approaches,spatiotemporal TIME heterogeneity will be further decoded,prompting personalized liver cancer immunotherapy strategies based on distinct spatiotemporal TIME patterns.Advances in spatiotemporal TIME heterogeneity research will ultimately bring benefits to patients in clinical settings.

关 键 词：肿瘤微环境 时空异质性 免疫治疗 肿瘤异质性 

分 类 号：R735.7[医药卫生—肿瘤]