三级淋巴样结构与抗肿瘤免疫  

Tertiary Lymphoid Structure and Antitumor Immunity

作　　者：翁小淇 苏士成[1] 陆艺文 WENG Xiaoqi;SU Shicheng;LU Yiwen(Breast Tumor Center,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院乳腺肿瘤中心,广州510120

出　　处：《中国细胞生物学学报》2022年第4期627-638,共12页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:91942309,82125017,92057210,82002780);广州市科技计划项目(批准号:202103000070)资助的课题。

摘　　要：三级淋巴样结构(tertiary lymphoid structure,TLS),又称异位淋巴样器官(ectopic lymphoid organ,ELO),是形成于非淋巴组织中的异位淋巴样器官,通常发生在慢性炎症包括自身免疫病、感染性疾病和肿瘤等部位。TLS与淋巴结等淋巴器官有相似的结构,包含T细胞、B细胞、滤泡树突状细胞等多种免疫细胞。在肿瘤中,TLS可以作为免疫细胞进入肿瘤组织的通道,多与较好治疗反应和预后相关。诱导肿瘤组织中TLS形成是潜在的肿瘤治疗新策略。该文系统地综述了TLS的组成、结构、在肿瘤中的功能、与肿瘤预后的关联以及靶向TLS的相关治疗方案。TLSs(tertiary lymphoid structures),also known as ELOs(ectopic lymphoid organs),are organized aggregates of immune cells that localize in non-lymphoid tissues at sites of chronic inflammation,such as autoimmune diseases,infectious diseases and tumors.The structure of TLS is similar with that of lymph node,which composes of T cells,B cells,follicular dendritic cells,etc.TLS serves as an entry for immune cells to infiltrate in tumor tissues.The presence of TLS commonly correlates with a better therapeutic response and a longer survival.Here,this article reviewed the composition,structure,function,the role of TLS in tumor prognosis and therapeutic strategies targeting TLS.

关 键 词：三级淋巴样结构 肿瘤 预后 抗肿瘤免疫 

分 类 号：R730[医药卫生—肿瘤]