前列腺癌术后RapidArc与IMRT放疗计划的剂量学比较  

Dosimetry comparison study between RapidArc and IMRT planning for postoperative prostate cancer

作　　者：童铸廷[1] 周骏[2] 潘淑豪 李锐[1] 夏叶叶 朱倩倩 TONG Zhuting;ZHOU Jun;PAN Shuhao;LI Rui;XIA Yeye;ZHU Qianqian(Department of Radiation Oncology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Urology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Radiation Oncology,Fuyang Cancer Hospital,Fuyang 236010,China)

机构地区：[1]安徽医科大学第一附属医院肿瘤放疗科,安徽合肥230022 [2]安徽医科大学第一附属医院泌尿外科,安徽合肥230022 [3]安徽省阜阳市肿瘤医院肿瘤放疗科,安徽阜阳236010

出　　处：《安徽医学》2022年第9期1017-1021,共5页Anhui Medical Journal

基　　金：安徽省教育厅高等学校自然科学研究基金(项目编号:KJ2021A0295);安徽省高校优秀拔尖人才培育项目(项目编号:gxgwfx2018015)。

摘　　要：目的比较前列腺癌术后辅助放疗患者RapidArc与适形调强放疗(IMRT)计划在靶区和危及器官的剂量学差异。方法选择2020年7月至2022年2月在安徽医科大学第一附属医院接受术辅助放疗或者术后生化复发的前列腺癌患者14例,分别设计7野IMRT和RapidArc计划,对2种计划的靶区和危及器官的剂量学进行比较。结果RapidArc计划的D_(2%)为(6645.28±242.48)cGy,低于IMRT计划,差异具有统计学意义(P<0.05)。D_(2%)的下降导致RapidArc计划的靶区剂量均匀度指数优于IMRT计划(P<0.05);RapidArc计划的膀胱V_(40)和V_(50),直肠V_(50)以及左右侧股骨头D_(5%)均低于IMRT计划,差异有统计学意义(P<0.05)。RapidArc计划的执行效率高于IMRT计划,差异有统计学意义(P<0.05)。结论RapidArc计划在在靶区剂量均匀度,危及器官高剂量受照体积限制,以及机器跳数和治疗时间方面优于IMRT计划。Objective To compare the dosimetry differences between RapidArc and IMRT plan for patients diagnosed with prostate cancer.Methods Fourteen prostate cancer patients received post-prostatectomy or biochemical relapse radiotherapy therapy in the First Affiliated Hospital of Anhui Medical University were selected for this study.We designed RapidArc and IMRT plan for each prostate cancer patient respectively,and the dosimetric differences in target area and organs at risk(OAR)between RapidArc and IMRT was assessed.Results The D_(2%) of RapidArc(6645.28±242.48 cGy)was significantly lower than that of seven-field plan,and the difference was statistically significant(P<0.05),resulting inbetter homogeneity index.The bladder V_(40),V_(50) and rectum V_(50) and bilateral femoral head D_(5%)of RapidArc were obviously reduced than those of IMRT plan(P<0.05).In addition,the execution efficiency of RapidArc was significantly higher than that of IMRT plan(P<0.05).Conclusions RapidArc is superior to IMRT in terms of dose homogeneity of target volume,protection of organs at risk at high dose,machine unit number and treatment time.

关 键 词：前列腺癌 容积旋转调强放疗 RAPIDARC 适形调强放疗 剂量学 

分 类 号：R737.25[医药卫生—肿瘤]