环状RNA在眼科疾病发生发展中的作用机制研究进展  

Research progress on the effect of circRNA in the occurrence and development of ophthalmic diseases

作　　者：李华健 李鹏飞 陈雨欣 王勇[1] LI Huajian;LI Pengfei;CHEN Yuxin;WANG Yong(Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China)

机构地区：[1]南通大学附属医院眼科研究所,江苏省南通市226001

出　　处：《眼科新进展》2022年第9期739-743,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金面上项目(编号:81873676);中国博士后科学基金第68批次面上资助项目(编号:2020M681686)。

摘　　要：环状RNA(circRNA)是一种特殊类型的非编码RNA。它不同于包含5’帽和3’多聚尾的传统线性RNA,其具有闭环结构,不受RNA核酸外切酶的影响,所以结构稳定且不易降解。目前,人们已对circRNA在诸多疾病发病机制中的重要作用和生物功能展开深入研究,为各类眼科疾病的发病机制及诊疗提供新思路。本文就近年来circRNA在眼科疾病发生发展中的作用机制研究进展作一综述。CircRNA is a special type of non-coding RNA. Different from traditional linear RNAs containing 5’ caps and 3’ polyA tails, it has a closed-loop structure and is not affected by RNA exonuclease, so it is stable and non-degradable. At present, the important role and biological functions of circRNA in the pathogenesis of many diseases have been thoroughly studied, providing new ideas for the diagnosis and treatment of various ophthalmic diseases. In this paper, the recent advances in research on how circRNA affects the development of ophthalmic diseases are reviewed.

关 键 词：环状RNA 微小RNA 眼病 白内障 

分 类 号：R776.1[医药卫生—眼科]