Ⅰ型超敏反应新型诊断技术及免疫疗法研究进展  

Research progress of new diagnostic technology and immunotherapy for typeⅠhypersensitivity

作　　者：刘益 沙爱龙 LIU Yi;SHA Ailong(School of Biology and Food Engineering,Chongqing Three Gorges University,Wanzhou 404120,China;School of Teacher Education,Chongqing Three Gorges University,Wanzhou 404120)

机构地区：[1]重庆三峡学院生物与食品工程学院,重庆万州404120 [2]重庆三峡学院教师教育学院,重庆万州404120

出　　处：《中国比较医学杂志》2022年第8期116-122,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(31360635)。

摘　　要：Ⅰ型超敏反应为当代民众常发性疾病,其主要由IgE型抗体分子所介导,可引起一系列局部或全身性反应。为有效治疗Ⅰ型超敏反应类疾病,开发新型诊断技术及免疫疗法便成为其重点研究方向。目前已发现的新型诊断技术主要有过敏原成分决定性诊断(CRD)、嗜酸性细胞阳离子蛋白(ECP)检测及嗜碱性粒细胞活化实验(BAT)等。同时,其免疫疗法(AIT)亦发展迅速,世界各地的科研工作者开发出了多种免疫新疗法与新技术,主要包括特异性与非特异性两大类。基于此,本文主要对Ⅰ型超敏反应新型诊断技术及其免疫疗法的新进展做一概述,供相关研究者参考。Type I hypersensitivity is a common disease that is mainly mediated by IgE antibody molecules,resulting in a series of local or systemic reactions.To effectively treat type I hypersensitivity,the key research direction is the development of new diagnostic technologies and immunotherapies.The newly discovered diagnostic techniques include allergen component deterministic diagnosis,eosinophil cationic protein detection,and the basophil activation test.Immunotherapy has also developed rapidly,with researchers from around the world developing a variety of new specific and non-specific immunotherapies and technologies.This article summarizes the recent developments in type I hypersensitivity diagnosis technology and immunotherapy as a reference for future research.

关 键 词：Ⅰ型超敏反应 新型诊断技术 变应原检测 免疫疗法 

分 类 号：R-33[医药卫生]