血管内皮生长因子、单核细胞趋化蛋白1、分化抑制因子1在脑胶质瘤中的表达及与血管生成的相关性分析  

Expressions of vascular endothelial growth factor,monocyte chemotactic protein 1 and inhibitor of differentiation 1 in glioma and their correlations with angiogenesis

作　　者：吴佩涛 丁凡 欧阳伟 王少兵 Pei-tao Wu;Fan Ding;Wei Ouyang;Shao-bing Wang(Department of Neurosurgery,Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan,Hubei 430000,China;Spinal Cord Disease Center,Wuhan Puren Hospital,Wuhan,Hubei 430081,China)

机构地区：[1]湖北省中西医结合医院神经外科,湖北武汉430000 [2]武汉普仁医院脊髓病中心,湖北武汉430081

出　　处：《中国现代医学杂志》2022年第18期90-94,共5页China Journal of Modern Medicine

基　　金：中国金属学会冶金安全与健康分会健康卫生科研项目(No:jkws201824)。

摘　　要：目的 分析血管内皮生长因子(VEGF)、单核细胞趋化蛋白1(MCP-1)、分化抑制因子1(Id1)在脑胶质瘤中的表达及与血管生成的相关性。方法 选取2018年4月—2020年5月湖北省中西医结合医院脑胶质瘤患者150例作为病例组。另选取该院因脑外伤后行颅内减压术的50例非肿瘤患者(正常脑组织)作为对照组。对比两组患者血清VEGF、MCP-1、Id1水平,绘制ROC曲线分析血清VEGF、MCP-1、Id1水平预测脑胶质瘤发生的价值;比较不同级别脑胶质瘤患者血清VEGF、MCP-1、Id1水平及肿瘤微血管密度(MVD)值,Pearson法分析血清VEGF、MCP-1、Id1水平与MVD值的相关性。结果 病例组血清VEGF、Id1水平较对照组高,MCP-1水平较对照组低(P <0.05)。ROC曲线结果显示,血清VEGF、MCP-1、Id1水平及3者联合预测胶质瘤发生的AUC分别为0.873(95%CI:0.823,0.923)、0.776(95%CI:0.699,0.853)、0.898(95%CI:0.850,0.946)、0.908(95%CI:0.851,0.978)。高级别组血清VEGF、Id1水平及MVD较低级别组高,MCP-1水平较低级别组低(P <0.05)。Pearson相关性分析显示,脑胶质瘤患者MVD与血清VEGF水平、Id1水平呈正相关(r=0.532和0.697,均P <0.05),与MCP-1水平呈负相关(r=-0.395,P <0.05)。结论 脑胶质瘤患者血清VEGF、Id1水平上调,MCP-1水平下调,三项指标与肿瘤血管生成密切相关,且可有效预测胶质瘤的发生。Objective To analyze the expressions of vascular endothelial growth factor(VEGF),monocyte chemotactic protein 1(MCP-1),and inhibitor of differentiation 1(Id1) in glioma and their correlations with angiogenesis.Methods A total of 150 glioma patients admitted to Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine from April 2018 to May 2020 were selected as the case group,and 50non-tumor patients(with normal brain tissues) undergoing intracranial decompression after brain trauma were selected as the control group.The serum levels of VEGF,MCP-1 and Id1 were compared between the two groups.The values of these indicators in predicting the occurrence of glioma were determined via ROC curve analysis.The serum levels of VEGF,MCP-1 and Id1 as well as the intratumoral microvessel density(MVD) were compared among patients with different degrees of glioma.The correlations between the serum levels of VEGF,MCP-1 and Id1 and the intratumoral MVD were analyzed by the Pearson method.Results The serum levels of VEGF and Id1in the case group were higher than those in the control group(P < 0.05),while the serum level of MCP-1 was lower in the case group compared with the control group(P < 0.05).The ROC curve analysis revealed that the AUCs of serum levels of VEGF,MCP-1 and Id1 as well as their combination for predicting the occurrence of glioma were0.873(95% CI:0.823,0.923),0.776(95% CI:0.699,0.853),0.898(95% CI:0.850,0.946),and 0.908(95% CI:0.851,0.978),respectively.The serum levels of VEGF and Id1 and intratumoral MVD were higher,and the serum level of MCP-1 was lower in patients with high degrees of glioma than those in patients with low degrees of glioma(P < 0.05).The Pearson correlation analysis showed that the intratumoral MVD was positively correlated with the serum levels of VEGF(r = 0.532,P = 0.000) and Id1(r = 0.697,P = 0.000),but negatively correlated with the serum level of MCP-1(r =-0.395,P = 0.003).Conclusions In glioma patients,serum levels of VEGF and Id1 are upregulated while the serum l

关 键 词：脑胶质瘤 血管内皮生长因子 单核细胞趋化蛋白1 分化抑制因子 血管生成 

分 类 号：R739.41[医药卫生—肿瘤]