不同手术入路对脑肿瘤患者肿瘤切除率及血清指标的影响  

Effects of different surgical approaches on tumor resection rate and serum markers in patients with brain tumors

作　　者：胡志平[1] 郑钟[1] 刘庭富 陈彦蓉 周珍贵 HU Zhiping;ZHENG Zhong;LIU Tingfu;CHEN Yanrong;ZHOU Zhengui(Department of Brain Surgery,Gongan County People's Hospital,Jingzhou,Hubei,China,434300)

机构地区：[1]公安县人民医院脑外科,湖北荆州434300

出　　处：《分子诊断与治疗杂志》2022年第9期1472-1475,共4页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省卫生健康委第一批联合基金立项项目(WJ2019HJ020)。

摘　　要：目的分析不同手术入路对脑肿瘤患者肿瘤切除率及血清炎性因子等指标的影响。方法选取2016年1月至2020年6月湖北省荆州市公安县人民医院脑外科接受颅脑肿瘤切除术患者84例为研究对象,根据患者颅脑肿瘤位置的不同,给予相应的手术入路,观察其治疗效果。结果本次研究患者中肿瘤总切除率为92.85%,其中颅前窝底肿瘤、蝶骨嵴脑膜瘤切除率高达100%;患者在术后其头痛、头晕、视乳头水肿、恶心呕吐及癫痫等临床症状明显改善,差异有统计学意义(χ^(2)=131.574、144.932、111.446、127.043、49.130,P<0.05);患者在术前疼痛程度评分明显高于术后,差异有统计学意义(χ^(2)=59.267,P<0.05);手术治疗后的IL-8、MBP、ETS-1及NSE均较手术前高,但不同手术入路患者间IL-8、MBP、ETS-1及NSE数据比较,差异无统计学意义(P>0.05)。结论根据患者颅脑肿瘤位置的不同,选择与其相对应的手术入路,能明显改善患者的临床症状,改善血清指标水平,提升颅脑肿瘤的切除率。Objective To analyze the effects of different surgical approaches on tumor resection rate and serum inflammatory factors in patients with brain tumors.Methods From january 2016 to June 2020,84 patients who underwent Craniocerebral Tumor Resection in the Department of Brain Surgery of Gongan County People’s Hospital,Jingzhou City,Hubei Province were selected as the research objects.According to the different positions of patients’craniocerebral tumors,the corresponding surgical approaches were given to observe the therapeutic effects.Results The total resection rate of tumors in this study was 92.85%,among which the resection rate of anterior fossa tumors and sphenoid ridge meningioma was as high as 100%.After surgery,the patient’s clinical symptoms,such as headache,dizziness,papilledema,nausea and vomiting,and epilepsy were significantly improved,the difference was statistically significant(χ^(2)=131.574,144.932,111.446,127.043,49.130,P<0.05);The pain score of patients before operation was significantly higher than that after operation,and the difference was statistically significant(χ^(2)=59.267,P<0.05);After surgical treatment,Il-8,MBP,ETS-1 and NSE were higher than those before surgery,but there were no statistical differences in IL-8,MBP,ETS-1 and NSE among patients with different surgical approaches(P<0.05).Conclusion According to the different location of craniocerebral tumor,selecting the corresponding surgical approach can improve the clinical symptoms of patients and improve the resection rate of craniocerebral tumor.

关 键 词：手术入路 脑肿瘤 肿瘤切除率 血清指标 

分 类 号：R739.41[医药卫生—肿瘤]