肺癌患者ACTH、HGH、PRL和皮质醇联合检测价值分析  

Analysis of the value of combined detection of ACTH,HGH,PRL and cortisol in patients with lung cancer

作　　者：关堂胜 陈苗红 许岩 吴竞 GUAN Tangsheng;CHEN Miaohong;XU Yan;WU Jing(Department of Clinical Laboratory,the Second Affiliated Hospital of Wannan Medical College,Wuhu,Anhui,China,241000)

机构地区：[1]皖南医学院第二附属医院检验科,安徽芜湖241000

出　　处：《分子诊断与治疗杂志》2022年第9期1558-1561,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81601806)。

摘　　要：目的促肾上腺皮质激素(ACTH)、人生长激素(HGH)、泌乳素(PRL)和皮质醇(CORT)联合检测肺癌的价值分析。方法选取2018年1月到2021年12月皖南医学院第二附属医院及皖南医学院附属弋矶山医院收治的86例肺癌患者为肺癌组,并选取同期患有良性肺部疾病的患者50例为对照组。分析两组患者血清的ACTH、HGH、PRL和CORT水平情况,探究其联合检测对肺癌预测价值。随访一年,根据预后情况将患者分为预后良好组和预后不良组,收集患者的相关资料,采用Logistic因素分析ACTH、HGH、PRL和CORT水平与肺癌患者预后的关系。结果肺癌组患者的ACTH、HGH、PRL水平明显高于良性肺部疾病组患者,CORT水平明显低于良性肺部疾病疾病组,差异有统计学意义(t=10.003、8.294、10.234、7.569;P均<0.05)。以ACTH、HGH、PRL和CORT含量变化的数据建立ROC分析模型,四者及联合检测曲线下面积分别为0.636、0.583、0.597、0.613和0.758,联合检测对肺癌具较高的预测价值(P<0.05)。预后不良组患者血清中ACTH、HGH、PRL水平均高于预后良好组,CORT水平低于预后良好组,差异有统计学意义(t=2.489、3.127、2.306、2.690;P均<0.05)。Logistic回归分析显示,吸烟、肺腺癌病理分型、血清中ACTH、HGH、PRL、CORT水平变化均是患者预后不良的独立危险因素(P<0.05)。结论ACTH、HGH、PRL和CORT联合检测对肺癌具有较高的预测价值,且吸烟、肺腺癌病理分型、ACTH、HGH、PRL、CORT水平变化均是影响肺癌患者预后不良的因素,在临床中可相应做好的诊疗措施。Objective To analyze the value of adrenocorticotropic hormone(ACTH),human growth hormone(HGH),prolactin(PRL)and cortisol(CORT)combined detection in lung cancer.Methods A total of 86 lung cancer patients admitted to the Second Affiliated Hospital of Wannan Medical College and the First Affiliated Hospital of Wannan Medical College from January 2018 to December 2021 were selected as the lung cancer group,and 50 patients with benign lung disease during the same period were selected as the control group.The serum levels of ACTH,HGH,PRL and CORT in two groups were analyzed to explore the predictive value of combined detection for lung cancer.Patients were followed up for one year and divided into the good prognosis group and the poor prognosis group according to prognosis.Relevant data of patients were collected,and Logistic factors were used to analyze the relationship between ACTH,HGH,PRL and CORT levels and prognosis of patients with lung cancer.Results The levels of ACTH,HGH and PRL in the lung cancer group were significantly higher than those in the benign lung disease group,and the level of CORT was significantly lower than that in the benign lung disease group,and the differences were statistically significant(t=10.003,8.294,10.234,7.569;P<0.05).The ROC analysis model was established based on the changes of ACTH,HGH,PRL and CORT levels.The areas under the curves of the four methods and the combined method were0.636,0.583,0.597,0.613 and 0.758,respectively.The combined method has high predictive value for lung cancer.The serum ACTH,HGH and PRL levels in the poor prognosis group were higher than those in the good prognosis group,and the CORT level was lower than that in the good prognosis group,the difference was significant(t=2.489、3.127、2.306、2.690;P<0.05).Logistic regression analysis showed that smoking,pathological classification of lung adenocarcinoma and changes in serum levels of ACTH,HGH,PRL and CORT were independent risk factors for poor prognosis(P<0.05).Conclusion The combined detection of ACTH,H

关 键 词：肾上腺皮质激素 人生长激素 泌乳素 皮质醇 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]