肺腺癌CT征象与Ki67、PNCA及p53蛋白的相关性  

Correlation between CT signs of lung adenocarcinoma and Ki67,PNCA and p53 protein

作　　者：卢艳丽 万宏燕 吴俊 LU Yanli;WAN Hongyan;WU Jun(Department of Radiology,Beijing Longfu Hospital,Beijing,China,100010)

机构地区：[1]北京市隆福医院放射科,北京100010

出　　处：《分子诊断与治疗杂志》2022年第9期1590-1593,1597,共5页Journal of Molecular Diagnostics and Therapy

基　　金：东城区卫生科技计划项目(编号:东卫健研[2021-9])。

摘　　要：目的分析肺腺癌CT征象与Ki67、增殖细胞核抗原(PNCA)、p53蛋白的相关性。方法选取2019年8月至2021年1月北京市隆福医院收治的187例肺腺癌患者临床资料,均在手术后病理证实为肺腺癌者,以患者癌组织作为观察组,取距离癌组织5 cm处癌旁组织作为对照组。比较不同组织中Ki67、PNCA、p53蛋白表达情况,分析肺腺癌CT征象,探讨肺腺癌CT征象与Ki67、PNCA、p53蛋白的相关性。结果观察组中Ki67、PNCA、p53蛋白表达阳性率明显高于对照组,差异有统计学意义(P<0.05)。187例患者CT图像可见:患者病灶多为实性结节,边界不清晰;同时可见胸膜凹陷征、毛刺征、空泡征、分叶征、胸腔积液。有分叶征、毛刺征患者Ki67表达阳性率明显高于无分叶征、毛刺征患者,差异有统计学意义(P<0.05),不同胸膜凹陷征、肿瘤边界、结节类型、胸腔积液患者Ki67表达情况比较差异无统计学意义(P>0.05)。有分叶征、胸膜凹陷征、空泡征患者PNCA表达阳性率明显高于无分叶征、胸膜凹陷征、空泡征患者,差异有统计学意义(P<0.05),不同肿瘤边界、毛刺征、结节类型、胸腔积液患者PNCA表达情况比较差异无统计学意义(P>0.05)。有毛刺征、肿瘤边界不清晰患者p53表达阳性率明显高于无毛刺征、肿瘤边界清晰患者,差异有统计学意义(P<0.05),不同胸膜凹陷征、空泡征、结节类型、分叶征、结节类型、胸腔积液患者p53表达情况比较差异无统计学意义(P>0.05)。结论Ki67、PNCA、p53蛋白表达情况与肺腺癌CT征象存在一定相关性,对肺腺癌的早期诊断及预后评估有一定的参考价值。Objective To analyze the correlation between CT signs of lung adenocarcinoma and Ki67,proliferating cell nuclear antigen(PNCA)and p53 protein.Methods The clinical data of 187 patients with lung adenocarcinoma admitted to Beijing Longfu Hospital from August 2019 to January 2021 were selected,all patients were pathologically confirmed with lung adenocarcinoma after surgery,the cancer tissue of the patient was used as the observation group,and the no cancerous tissue 5 cm next to the cancer were selected as the control group.The protein expressions of Ki67,PNCA and p53 in different tissues were compared,and the CT signs of lung adenocarcinoma were analyzed to explore the correlation between the CT signs of lung adenocarcinoma and Ki67,PNCA and p53 proteins.Results The positive rates of Ki67,PNCA,and p53 protein expression in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).CT images of 187 patients were visible,the lesions were mostly solid nodules,with unclear borders;at the same time pleura depression sign,burr sign,vacuole sign,lobular sign,pleural effusion were visible;the positive rate of Ki67 expression in patients with lobular sign and burr sign was significantly higher than that in patients without lobular sign and burr sign,and the difference was statistically significant(P<0.05).There was no statistically significant difference in Ki67expression among patients with different pleural indentation signs,tumor borders,nodule types,and pleural effusions(P>0.05).The positive rate of PNCA expression in patients with lobular sign,pleural depression,and vacuole sign was significantly higher than that in patients without lobular sign,pleural depression,and vacuole signs,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the expression of PNCA among patients with different tumor borders,burr signs,nodule types,and pleural effusion(P>0.05).The positive rate of p53 expressio

关 键 词：肺腺癌 CT征象 KI67 PNCA P53蛋白 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]