青少年口腔正畸口腔微生态与继发口腔念珠菌感染的关系  

Relationship between oral microecology and secondary oral candida infection in orthodontics adolescents

作　　者：吴丽娟 闫娅霏 陈萍 WU Li-juan;YAN Ya-fei;CHEN Ping(Department of Orthodontics,Yinchuan Stomatological Hospital,Ningxia Yinchuan 750004,China;Medical experimental center,General Hospial of Ningxia Medical Universiy,Ningxia Yinchuan 750004,China.)

机构地区：[1]银川市口腔医院正畸科,宁夏银川750004 [2]宁夏医科大学总医院医学实验中心,宁夏银川750004

出　　处：《临床口腔医学杂志》2022年第8期470-473,共4页Journal of Clinical Stomatology

摘　　要：目的:探讨青少年口腔正畸口腔微生态与继发口腔念珠菌感染的关系。方法:选取我院2019年1月~2022年1月收治的60例进行口腔正畸后继发口腔念珠菌感染患者作为感染组,随机选择同期60例未发生口腔念珠菌感染患者作为未感染组。对比两组患者性别、糖尿病、低蛋白血症、鼻炎、胃炎、哮喘、矫治器类型年龄、体重指数(BMI)、糖尿病、等数据;采用多因素Logistic回归分析继发口腔念珠菌感染危险因素;对比两组患者口腔牙龈卟啉单胞菌(Pg)、伴放线菌(Aa)、福赛坦氏菌(Tf)及中间普氏菌(Pi)检出率。结果:感染组中BMI≥24 kg·m^(-2)、存在糖尿病、存在低蛋白血症、存在高血压人数均明显高于非感染组,且戴有无托槽隐形正畸矫治器人数明显低于非感染组(P<0.05);糖尿病、低蛋白血症为继发口腔念珠菌感染形成独立危险因素(P<0.05);感染组口腔Pg、Aa、Tf及Pi检出率均明显高于非感染组(P<0.05);在感染组中,合并糖尿病者Pg检出率明显高于无糖尿病者,存在低蛋白血症者Aa、Tf及Pi检出率明显高于无低蛋白血症者(P<0.05)。结论:糖尿病、低蛋白血症均为青少年口腔正畸治疗后继发口腔念珠菌感染的独立危险因素,可能通过影响患者口腔微生态平衡,从而增加继发口腔念珠菌感染的风险。Objective:To explore the relationship between oral microecology and secondary oral candida infection in orthodontics adolescent.Methods:A total of 60 patients with secondary oral candida infection after orthodontics admitted to the hospital were enrolled as infection group between January 2019 and January 2022,while other 60 patients without infection during the same period were enrolled as non-infection group.Gender,diabetes,hypoproteinemia,rhinitis,gastritis,asthma,appliance type,age,body mass index(BMI),diabetes,and other data were compared between the two groups.The risk factors of secondary oral candida infection were analyzed by multivariate Logistic regression analysis.The detection rates of Porphyromonas gingivalis(Pg),Actinomycetes actinomycetemcomitans(Aa),Tannella forsythia(Tf)and Prevotella intermedia(Pi)were compared between the two groups.Results:The number of cases with BMI≥24 kg·m^(-2),diabetes mellitus,hypoalbuminemia,and hypertension in infection group was significantly more than that in non-infection group,while number of cases with non-bracket invisible appliance was significantly less than that in non-infection group(P<0.05).Diabetes mellitus and hypoalbuminemia were independent risk factors of secondary oral candida infection(P<0.05).The detection rates of oral Pg,Aa,Tf and Pi in infection group were significantly higher than those in non-infection group(P<0.05).In infection group,detection rate of Pg in patients with diabetes mellitus was significantly higher than that without diabetes mellitus.The detection rates of Aa,Tf and Pi in patients with hypoalbuminemia were significantly higher than those without hypoproteinemia(P<0.05).Conclusion:Diabetes mellitus and hypoalbuminemia are independent risk factors of secondary oral candida infection in adolescents after orthodontics,which may increase the risk of secondary oral candida infection by affecting the balance of oral microecology.

关 键 词：口腔正畸 口腔微生态 口腔念珠菌感染 危险因素 

分 类 号：R783.5[医药卫生—口腔医学] R780.2[医药卫生—临床医学]