TLR4受体在肿瘤中的研究进展  

Research progress of TLR4 receptor in tumor

作　　者：王思思 王泽友 李慧洋 任碧琼 WANG Sisi;WANG Zeyou;LI Huiyang;REN Biqiong(School of Clinical Medicine,Hunan University of Chinese Medicine/the Second People's Hospital of Hunan Province,Changsha,410007,Hunan,China;Department of Laboratory Medicine,the Second Xiangya Hospital,Central South University,Changsha,410011,Hunan,China)

机构地区：[1]湖南中医药大学临床医学院/湖南省第二人民医院,湖南长沙410007 [2]中南大学湘雅二医院检验医学科,湖南长沙410011

出　　处：《肿瘤药学》2022年第4期455-464,共10页Anti-Tumor Pharmacy

基　　金：湖南省中医药管理局(2021033);湖南中医药大学2021年度医学技术一级学科开放基金(2021YXJS03)。

摘　　要：随着生命科学和现代生物医学的快速发展,人类对肿瘤有了深入认识,并且积极主动寻找治疗肿瘤的有效手段。Toll样受体4(TLR4)是第一个被发现并报道的可调节炎症反应的TLR家族成员。目前的研究显示,TLR4可通过髓样分化因子依赖性通路和非依赖性通路,介导包括肿瘤免疫、肿瘤炎症、肿瘤侵袭转移、肿瘤药物治疗等诸多过程。本文综述了TLR4在肿瘤中的最新研究进展,旨在讨论TLR4在肿瘤发生发展中的作用,为生命科学和临床医学提供更多理论依据。With the rapid development of life science and modern biomedicine,humans have had a deep understanding of tumors,and have been actively seeking effective means to treat tumors.Toll-like receptor 4(TLR4) is the first TLR family member identified and reported to regulate inflammatory response.Current studies have shown that TLR4 is involved in mediating many processes including tumor immunity,tumor inflammation,tumor invasion and metastasis,and tumor drug therapy,through myeloid differentiation factor-dependent and independent pathways.This review summarized the recent progress of TLR4 receptor in tumor research,and discussed the roles of TLR4 in tumor genesis and development,so as to provide some theoretical basis for life science and clinical medicine.

关 键 词：TLR4 肿瘤 研究进展 

分 类 号：R730.3[医药卫生—肿瘤]