行波离子迁移谱的行波脉冲电源设计及应用  

Design and Application of a Traveling Wave Pulse Power Supply for Traveling Wave Ion Mobility Spectrometry

作　　者：李宏[1] 邓辅龙 郭星 吕炎曈 岳寒露 王如新 杨燕婷 赵忠俊[5] 段忆翔[1] LI Hong;DENG Fu-long;GUO Xing;LYU Yan-tong;YUE Han-lu;WANG Ru-xin;YANG Yan-ting;ZHAO Zhong-jun;DUAN Yi-xiang(College of Life Science,Sichuan University,Chengdu 610044,China;College of Chemistry and Materials Science,Northwest University,Xi’an 710127,China;School of Chemical Engineering,Sichuan University,Chengdu 610044,China;Chengdu Aliben Technology Co.,Ltd.,Chengdu 611930,China;School of Mechanical Engineering,Sichuan University,Chengdu 610044,China)

机构地区：[1]四川大学生命科学学院,四川成都610044 [2]西北大学化学与材料科学学院,陕西西安710127 [3]四川大学化学工程学院,四川成都610044 [4]成都艾立本科技有限公司,四川成都611930 [5]四川大学机械工程学院,四川成都610044

出　　处：《质谱学报》2022年第5期679-686,I0008,共9页Journal of Chinese Mass Spectrometry Society

基　　金：四川省重大科学仪器设备专项(2019ZDZX0036)。

摘　　要：基于行波的无损离子操作结构装置(TW-SLIM)是一种新型的可实现复杂气相离子操作的离子漂移管,是行波离子迁移谱(TWIMS)的核心器件,其利用行波脉冲电源提供振荡电场实现离子传输和分离。针对行波无损离子操作结构特性,采用现场可编程逻辑门阵列(FPGA)作为行波脉冲信号源,使用集成半桥驱动器作为栅极驱动,以金属氧化物半导体场效应管(MOSFET)构成的半桥拓扑电路作为脉冲输出级,使用可调高压电源作为半桥电路的直流母线电源,设计了一种行波脉冲电源。脉冲电源输出脉冲电压最大频率可达100 kHz,峰-峰值可达200 V,上升时间和下降时间均小于20 ns。在实验室自制的行波离子迁移谱仪器平台上测试了行波幅值和频率对离子传输和离子分离的影响。结果表明,当频率为10 kHz、幅值为35 V时,六(2,2-二氟乙氧基)磷腈的传输效率最高;在行波幅值不变时,随着行波频率的增大,离子信号强度减小。利用六(2,2-二氟乙氧基)磷腈和六(1H,1H,3H-全氟丙氧基)磷氮烯探究行波幅值和频率对离子基于结构分离情况的影响,在行波幅值不变时,随着行波频率增大,对2种离子的分离能力变强;在频率不变时,随着行波幅值增大,对2种离子的分离能力变弱。实验结果为行波离子迁移谱中的离子传输与分离机制提供了基本理解,该行波脉冲电源对于高分辨率TWIMS研发具有重要价值。Ion mobility(IM)coupled mass spectrometry(MS)is a versatile tool for analytical separations,characterization,and detection by measuring collision cross-sections and mass-to-charge(m/z)ratios.Traveling wave(TW)-based structures for lossless ion manipulations(TW-SLIM)is an innovative ion drift tube for complex gas phase ion manipulations,which is the key component of traveling wave ion mobility spectrometry(TWIMS).TW-SLIM combines flexible ion path design and traveling wave technology.The traveling wave pulse power supply is used to provide an oscillatory electric fields.Ions in TWIMS are propelled and separated by traveling wave.The operating pressure,TW amplitude and TW frequency of TW pulse have effect on ion motion in TWIMS.In this work,a traveling wave pulse power supply was developed,which mainly consisted of field programmable gate array(FPGA),half-bridge gate driver integrated circuit(IC),metal-oxide-semiconductor field effect transistor(MOSFET),adjustable high voltage module and external trigger signal.The frequency of TW pulse power supply was up to 100 kHz,both rising edge and falling edge were less than 20 ns.The influence of TW amplitude and TW frequency on ions transmission and separation was explored on the home-built instrument platform.The experimental results presented here provide a fundamental understanding of the transmission and separation mechanism in TWIMS.The maximum signal intensity of hexakis(2,2-difluoroethoxy)phosphazene was at amplitude of 35 V and frequency of 10 kHz.As the traveling wave frequency increased at a fixed traveling wave amplitude,signal intensity of hexakis(2,2-difluoroethoxy)phosphazene decreased.Ions separations was positively related to frequency when traveling wave amplitude was fixed,while traveling wave amplitude was opposite.The development of traveling wave pulse power supply is valuable for research and development of high resolution TWIMS instrument.

关 键 词：行波离子迁移谱(TWIMS) 无损离子操作结构 行波脉冲电源 半桥电路 

分 类 号：O657.63[理学—分析化学]