Research progress of autophagy in acute lung injury induced by multiple factors  

作　　者：Qiu-Cheng Li Qi Li Pan-Hong Jia Shao-Ning Li Xiao-Man Xiong Xiang-Dong Zhou 

机构地区：[1]Department of Respiratory Medicine,the First Affiliated Hospital of Hainan Medical College,Haikou 570102,China [2]Key Laboratory of Hainan Trauma and Disaster Rescue,Haikou 571199,China [3]Research Unit of Island Emergency Medicine,Chinese Academy of Medical Sciences 2019RU013,Hainan Medical University,Haikou 571199,China

出　　处：《Journal of Hainan Medical University》2022年第15期64-70,共7页海南医学院学报（英文版）

基　　金：Hainan Natural Science Foundation for Innovation Research Team(No.820CXTD448);Hainan Key R&D International Science and Technology Cooperation Project(GHYF2022011);the Scientific and Technology Cooperation of Key Research and Development in Hainan Province(No.ZDYF2020223);Major Science and Technology Special Projects in Hainan Province(No.ZDKJ2021036);National Natural Science Foundation of China(No.81860001,82011530049,82160012);It was also a project supported by Hainan Provincial Clinical Medical Center.

摘　　要：Autophagy is a highly conserved catabolic process, involving the degradation of cellular components, including damaged organelles, denatured proteins and various pathogens. It is a defense and stress mechanism for maintaining cell and tissue homeostasis. More and more evidences show that autophagy is closely related to many diseases. Acute lung injury is caused by intrapulmonary or extrapulmonary factors, with hypoxia and low lung compliance as the main manifestations. At present, its pathogenesis is not clear. It is known that the imbalance of inflammatory response and oxidative stress mechanism are the important mechanisms of its occurrence. The inflammatory response caused by acute lung injury has been reported to involve a series of changes in autophagy expression. Autophagy may be protective or harmful in acute lung injury. This article will summarize the respective roles of autophagy in acute lung injury caused by infectious factors (such as pathogen infection, lipopolysaccharide, sepsis) and non-infectious factors (acute pancreatitis, chlorine poisoning), so as to provide new ideas and strategies for better prevention of acute lung injury.

关 键 词：AUTOPHAGY Acute lung injury Infectious factors Non-infectious factors 

分 类 号：R563[医药卫生—呼吸系统]