脑出血患者血清B淋巴细胞瘤-2水平与功能预后的相关性  

Correlation between serum B-lymphoma-2 level and functional prognosis in patients with cerebral hemorrhage

作　　者：林锋[1] 宋鹏 谭博[1] 印晓鸿 钟冬胜[1] Lin Feng;Song Peng;Tan Bo;Yin Xiaohong;Zhong Dongsheng(Department of Neurosurgery,Guangyuan Central Hospital,Guangyuan 628000,China)

机构地区：[1]四川省广元市中心医院神经外科,628000

出　　处：《心脑血管病防治》2022年第4期69-72,76,共5页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的探讨脑出血患者血清B淋巴细胞瘤-2(Bcl-2)水平与功能预后的相关性。方法选取2018年10月至2021年3月四川省广元市中心医院收治的脑出血患者216例,随访3个月,观察患者功能预后情况,根据改良版Rankin量表(mRS)评分分为预后良好组(mRS<2分)和预后不良组(mRS≥2分)。收集两组一般资料、实验室指标、血清Bcl-2水平等,采用多因素Logistic回归分析影响脑出血患者功能预后的相关因素,采用限制性立方条图拟合血清Bcl-2水平与脑出血患者功能预后间的非线性关系。结果截止2021年6月1日,预后不良组78例(36.11%),预后良好组138例(63.89%)。两组入院时收缩压、中线移位、超敏C-反应蛋白(hs-CRP)、超敏心肌肌钙蛋白(hs-cTn)、美国国立卫生研究院卒中量表(NIHSS)、Bcl-2水平对比差异具有统计学意义(t=2.048、12.282、5.971、6.120、5.183、4.837,P<0.05);多因素Logistic回归分析显示:中线移位、hs-cTn、NIHSS评分、hs-CRP、Bcl-2水平为脑出血患者功能预后的危险因素[OR(95%CI)=31.846(11.913~85.134)、1.149(1.038~1.270)、1.160(1.026~1.312)、1.156(1.028~1.299)、1.160(1.065~1.265),P<0.05];限制性立方条图显示,血清Bcl-2水平与脑出血患者功能预后风险呈显著非线性关系(χ^(2)=11.950,P<0.05)。结论血清Bcl-2水平与脑出血患者功能预后相关。Objective To explore the correlation between serum B-lymphocyte tumor-2(Bcl-2)level and functional prognosis in patients with cerebral hemorrhage.Methods 216 patients with cerebral hemorrhage admitted to Sichuan Guangyuan Central Hospital from October 2018 to March 2021were selected.After 3 months follow-up,their functional prognosis were observed.According to the modified Rankin Scale(mRS)score,they were divided into good prognosis group(mRS<2 points)and poor prognosis group(mRS≥2 points).The general information,laboratory indicators and serum Bcl-2levels of the two groups were collected.Multivariate Logistic regression was used to analyze the related factors affecting the functional prognosis of patients with cerebral hemorrhage,and the restricted cube bar graphs were used to fit the nonlinear relationship between serum Bcl-2 levels and functional prognosis of patients with cerebral hemorrhage.Results As of June 1,2021,there were 78 cases(36.11%)in the poor prognosis group and 138 cases(63.89%)in the good prognosis group.On admission,systolic blood pressure,midline shift,high-sensitivity C-reactive protein(hs-CRP),high-sensitivity cardiac troponin(hs-cTn),National Institutes of Health Stroke Scale(NIHSS)score and Bcl-2 level had statistically significant differences between the two groups(t=2.048,12.282,5.971,6.120,5.183,4.837;P<0.05).Multivariate Logistic regression analysis showed that midline shift,hs-cTn,NIHSS score,hs-CRP and Bcl-2 levels were risk factors for functional prognosis in patients with cerebral hemorrhage[OR(95%CI)=31.846(11.913-85.134),1.149(1.038-1.270),1.160(1.026-1.312),1.156(1.028-1.299),1.160(1.065-1.265);P<0.05].Restricted cube bar graphs showed that serum Bcl-2 levels had a significant non-linear relationship with the functional prognosis risk of patients with cerebral hemorrhage(χ^(2)=11.950,P<0.05).Conclusion Serum Bcl-2 level is related to the functional prognosis of patients with cerebral hemorrhage.

关 键 词：血清B淋巴细胞瘤-2 脑出血 功能预后 细胞凋亡 

分 类 号：R743.34[医药卫生—神经病学与精神病学]