牙周组织再生术后行口腔正畸治疗对牙周炎患者龈沟液中炎症因子水平的影响  

Application value of periodontal tissue regeneration combined with orthodontics in patients with periodontitis

作　　者：晏燕[1] 陈先卓[2] YAN Yan;CHEN Xianzhuo(Department of Stomatology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Plastic Surgery and Burn,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院口腔科,四川南充637000 [2]川北医学院附属医院整形美容烧伤科,四川南充637000

出　　处：《贵州医科大学学报》2022年第8期973-977,共5页Journal of Guizhou Medical University

基　　金：南充市市校战略合作项目(18SXHZ0326)。

摘　　要：目的 探究牙周组织再生术后行口腔正畸治疗对牙周炎患者的疗效及龈沟液中炎症因子水平的影响。方法 42例牙周组织再生术联合口腔正畸治疗的牙周炎患者为观察组,选同时段行牙周组织再生术的42例牙周炎患者为对照组,比较两组患者治疗6个月时的临床疗效,采用疼痛视觉模拟评分量表(VAS)评估患者疼痛情况;于治疗前及治疗6个月时,采用酶联免疫吸附法检测龈沟液炎症因子白细胞介素-5(IL-5)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和白介素-1β(IL-1β)水平,比较两组患者牙龈指数(GI)、龈沟出血指数(SBI)、牙菌斑指数(PLI)、临床附着丧失(AL)等牙龈指标,牙槽骨密度及骨缺损高度差异。结果 治疗6个月时,观察组总有效率高于对照组,差异有统计学意义(P<0.05);VAS评分,IL-5、IL-6、IL-1β、TNF-α水平和GI、SBI、PLI、AL水平均低于对照组,差异有统计学意义(P<0.05);治疗后,两组患者牙槽骨密度、骨缺损高度均升高,且观察组牙槽骨密度、骨缺损高度高于对照组,差异有统计学意义(P<0.05)。结论 于牙周组织再生术后行口腔正畸治疗可显著提高牙周炎患者的治疗效果,其机制可能与联合治疗降低龈沟液中炎症因子水平有关。Objective To explore the effect of orthodontic treatment after periodontal tissue regeneration on patients with periodontitis and the level of inflammatory factors in gingival crevicular fluid.Methods Forty-two patients with periodontitis who underwent periodontal tissue regeneration combined with orthodontic treatment were selected as the observation group, and 42 patients with periodontitis who underwent periodontal tissue regeneration during the same period were selected as the control group.The clinical efficacy of the two groups 6 months after treatment was compared, and the pains of patients were evaluated by visual analogue scale of pain(VAS);Before and 6 months after treatment, the inflammatory factors interleukin-5(IL-5), interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β) in gingival crevicular fluid were detected by enzyme-linked immunosorbent assay.Gingival index( GI), sulcus bleeding index( SBI), plaque index( PLI),clinical attachment loss(AL),and other gingival indicators, alveolar bone mineral density and bone defect height were compared between the two groups.Results Six months after the treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P< 0.05).VAS score, the levels of IL-5, IL-6, IL-1β, TNF-α,GI,SBI, PLI, and AL were lower than those in the control group, and the difference was statistically significant(P< 0.05);after treatment, the alveolar bone density and bone defect height of the two groups increased, and the alveolar bone density and bone defect height of the observation group were higher than those of the control group, the difference was statistically significant(P< 0.05).Conclusion Orthodontic treatment after periodontal tissue regeneration can significantly promote the treatment effect of patients with periodontitis, and its mechanism may be related to the reduction of inflammatory factors in gingival crevicular fluid by combined treatment.

关 键 词：牙周组织再生术 口腔正畸 牙周炎 VAS评分 炎性因子 

分 类 号：R783.5[医药卫生—口腔医学]