帕罗西汀治疗产后抑郁症的效果及对炎性因子水平与性激素代谢的影响  

Efficacy of paroxetine in the treatment of postpartum depression patients and its effect on their inflammatory factor levels and sex hormone metabolism

作　　者：李金艳 LI Jinyan(Xianyang Hospital of Yan’an University,Xianyang 712000,China)

机构地区：[1]延安大学咸阳医院,咸阳712000

出　　处：《国际精神病学杂志》2022年第4期689-691,695,共4页Journal Of International Psychiatry

摘　　要：目的分析帕罗西汀应用于产后抑郁症患者的效果及对炎性因子水平与性激素代谢影响。方法选取135例产后抑郁症患者按照随机数字表法分为两组。对照组67例采取心理干预治疗,观察组68例采取帕罗西汀治疗;两组患者均治疗4周;观察两组患者治疗效果、神经递质水平、性激素水平、炎性因子水平及不良反应。结果观察组临床疗效高于对照组(P<0.05);观察组爱丁堡产后抑郁量表(EPDS)评分、汉密顿抑郁量表(HAMD)评分、皮质醇、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平较对照组低,雌二醇(E2)、黄体酮(P)、多巴胺(DA)、去甲肾上腺素(NE)、5羟色胺(5-HT)水平较对照组高(P<0.05);两组的不良反应的差别无统计学意义(P>0.05)。结论帕罗西汀能够有效调节产后抑郁症患者神经递质及炎性因子水平,改善患者性激素代谢,安全性高。Objective To analyze the effect of paroxetine in patients with postpartum depression and its effect on their inflammatory factor levels and sex hormone metabolism.Methods A total of 135 patients with postpartum depression were selected and divided into two groups according to the random number table method.67 cases in the control group were treated with psychological intervention,and 68 cases in the observation group were treated with paroxetine;both groups were treated for 4 weeks;the treatment effect,neurotransmitter levels,sex hormone levels,inflammatory factor levels and adverse reactions were observed in the two groups.Results The clinical efficacy of the observation group was higher than that of the control group(P<0.05).The Edinburgh Postpartum Depression Scale(EPDS)score,Hamilton Depression Scale(HAMD)score,cortisol,interleukin-6(IL-6)score,Tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)levels in the observation group were lower than those in the control group,estradiol(E2),progesterone(P),dopamine(DA),norepinephrine(NE)and serotonin(5-HT)levels were higher than those in the control group(P<0.05).There were no significant different in adverse reactions between two groups(P>0.05).Conclusion Paroxetine can effectively regulate the levels of neurotransmitters and inflammatory factors in patients with postpartum depression,and improve their metabolism of sex hormones with high safety.

关 键 词：帕罗西汀 产后抑郁症 性激素 炎性因子 神经递质 

分 类 号：R749.05[医药卫生—神经病学与精神病学]