乳腺癌组织LncRNA PVT1 ABCG2 mRNA表达与病理特征间关系及KM曲线分析  

Relationship between LncRNA PVT1 and ABCG2 mRNA Expression and Pathological Characteristics in Breast Cancer Tissues and Analysis of KM Curve

作　　者：徐亮[1] 王杜娟[2] 谢倩 李松梅[1] 黄述斌[1] XU Liang(Chizhou People's Hospital,Anhui Chizhou 247000,China)

机构地区：[1]安徽省池州市人民医院病理科,安徽池州247000 [2]广东省东莞市厚街医院病理科,广东东莞523900

出　　处：《河北医学》2022年第9期1457-1462,共6页Hebei Medicine

基　　金：广东省基础与应用基础研究基金项目,(编号:2019A1515110188)。

摘　　要：目的:探讨乳腺癌组织长链非编码RNA浆细胞瘤异位变异基因1(LncRNA PVT1)、三磷酸腺苷结合转运蛋白G2(ABCG2)mRNA表达与病理特征间关系及KM曲线分析。方法:选取2017年1月至2018年12月我院接受手术治疗的80例乳腺癌患者的病例资料;术中留取乳腺癌组织和癌旁组织(距病灶2 cm),比较癌组织及癌旁组织LncRNA PVT1、ABCG2 mRNA表达,分析癌组织LncRNA PVT1、ABCG2 mRNA表达与病理特征的相关性,COX回归分析乳腺癌患者术后复发的影响因素,比较不同癌组织LncRNA PVT1、ABCG2 mRNA表达患者无病生存期。结果:癌组织LncRNA PVT1(0.076±0.011)、ABCG2 mRNA(3.27±0.45)表达高于癌旁组织(0.003±0.001)、(0.82±0.26)(t=59.114、42.165,P<0.05);癌组织LncRNA PVT1、ABCG2 mRNA表达与临床分期、病理分级、淋巴结转移有关(P<0.05);复发者癌组织LncRNA PVT1(0.084±0.010)、ABCG2 mRNA(3.75±0.59)表达高于未复发者(0.074±0.009)、(3.13±0.47)(t=4.048、4.644,P<0.05);COX回归分析显示,癌组织LncRNA PVT1、ABCG2 mRNA高表达均为术后复发独立危险因素(P<0.05);Kaplan-Meier生存分析显示,癌组织LncRNA PVT1、ABCG2 mRNA高表达者术后3年无病生存率低于低表达者(P<0.05)。结论:乳腺癌患者癌组织LncRNA PVT1、ABCG2 mRNA异常高表达,且与病理特征及无病生存期相关,有望成为新的治疗靶点。Objective:To explore the relationship between long-chain non-coding RNA plasmacytoma ectopic variant gene 1(LncRNA PVT1),adenosine triphosphate binding transporter G2(ABCG2)mRNA expression and pathological characteristics in breast cancer tissues,and analysis of KM curve.Methods:The case data of 80 breast cancer patients who underwent surgical treatment in our hospital between January 2017 and July 2018 were selected for retrospective study.During the operation,breast cancer tissues and adjacent tissues(2cm from the lesion)were collected to compare the expression of LncRNA PVT1 and ABCG2 mRNA in the cancer tissues and adjacent tissues.The correlation between LncRNA PVT1,ABCG2 mRNA expression and pathological characteristics in cancer tissues were analyzed.The expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues of patients with and without recurrence were compared.COX regression was used to analyze the correlation between LncRNA PVT1 and ABCG2 mRNA expressions and recurrence in cancer tissues.The disease-free survival of patients with LncRNA PVT1 and ABCG2 mRNA expression in different cancer tissues was compared.Results:The expression of LncRNA PVT1(0.076±0.011)and ABCG2 mRNA(3.27±0.45)in cancer tissues was higher than that in adjacent tissues(0.003±0.001),(0.82±0.26)(t=59.114,42.165,P<0.05);the expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues was related to clinical stage,pathological grade,and lymph node metastasis(P<0.05);the expression of LncRNA PVT1(0.084±0.010)and ABCG2 mRNA(3.75±0.59)in cancer tissues of relapsed patients was higher than that of non-relapsed patients(0.074±0.009),(3.13±0.47)(t=4.048,4.644,P<0.05);COX regression analysis showed that the high expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues were independent risk factors for postoperative recurrence(P<0.05);Kaplan-Meier survival analysis showed that patients with high expression of LncRNA PVT1 and ABCG2 mRNA in cancer tissues had a lower 3-year disease-free survival rate than those with low expression(P<0.05)

关 键 词：乳腺癌 长链非编码RNA浆细胞瘤异位变异基因1 三磷酸腺苷结合转运蛋白G2 无病生存期 

分 类 号：R737.9[医药卫生—肿瘤]