间隙连接蛋白45与结直肠癌患者的临床病理特征及预后的相关性分析  

Correlation between Connexin 45 and Clinicopathological Features and Prognosis of Colorectal Cancer Patients

作　　者：朱建华[1] 钱筱健 顾梦会 袁政[1] ZHU Jianhua;QIAN Xiaojian;GU Menghui(Suzhou Municipal Hospital,Jiangsu Suzhou 215002,China)

机构地区：[1]江苏省苏州市立医院肠胃外科,江苏苏州215002

出　　处：《河北医学》2022年第9期1564-1569,共6页Hebei Medicine

基　　金：江苏省苏州市2018年度科技发展计划项目,(编号:SYSD2018126)。

摘　　要：目的:分析间隙连接蛋白45(Cx45)与结直肠癌患者的临床病理特征及预后的相关性。方法:选择本院2016年1月至2019年1月收治的97例结直肠癌患者,采用组织芯片技术检测其病灶组织、癌旁组织、转移淋巴结组织Cx45表达水平,并比较不同临床病理特征、不同预后患者病灶组织Cx45表达差异,分析病灶组织Cx45表达特点与患者临床病理特征、预后的关联。结果:共获取病灶组织、癌旁组织各97份,转移淋巴结组织86份。病灶组织、转移淋巴结组织Cx45高表达率均高于癌旁组织,低表达率均低于癌旁组织,差异有统计学意义(P<0.05)。不同淋巴结转移状态、不同分化程度、不同TNM分期直肠癌患者病灶组织Cx45表达情况比较,差异有统计学意义(P<0.05)。病灶组织Cx45高表达患者总生存期(OS)及无病生存期(PFS)均较中低表达者更短,差异有统计学意义(P<0.05)。Cox回归模型结果显示,有淋巴结转移、分化程度低分化、TNM分期Ⅲ~Ⅳ期、病灶组织Cx45高表达均为影响结直肠癌患者OS的独立危险因素(P<0.05)。结论:不同淋巴结转移、分化程度、TNM分期结直肠癌患者病灶组织Cx45表达存在明显差异,除临床病理特征外,病灶组织Cx45高表达也与患者OS缩短直接相关。Objective:To analyze the correlation between connexin 45(Cx45)and clinicopathological features and prognosis of colorectal cancer patients.Methods:97 patients with colorectal cancer admitted to our hospital from January 2016 to January 2019 were selected,and the expression levels of Cx45 in their focus tissues,adjacent tissues,and metastatic lymph nodes were detected by tissue microarray technology.The expression differences of Cx45 in focus tissues of patients with different clinicopathological features and different prognoses were compared,and the relationship between the expression characteristics of Cx45 in focus tissues and clinical pathological features and prognosis of patients were analyzed.Results:A total of 97 lesions,97 adjacent tissues and 86 metastatic lymph node tissues were obtained.The high expression rate of Cx45 in lesions and metastatic lymph nodes was higher than that in adjacent tissues,and the low expression rate was lower than that in adjacent tissues,with statistical significance(P<0.05).The expression of Cx45 in rectal cancer patients with different lymph node metastasis,different degree of differentiation,and different TNM staging rhythm was statistically significant(P<0.05).The overall survival time(OS)and disease-free survival time(PFS)of patients with high expression of Cx45 were shorter than those with low expression of Cx45,and the difference was statistically significant(P<0.05).Cox regression model showed that lymph node metastasis,low differentiation degree,TNM stageⅢ~Ⅳ,and high expression of Cx45 in lesion tissues were independent risk factors for OS in patients with colorectal cancer(P<0.05).Conclusion:The expression of Cx45 in colorectal cancer patients with different lymph node metastasis status,differentiation degree,and TNM stage are significantly different.Besides the clinicopathological features,the high expression of Cx45 in colorectal cancer patients is also directly related to the shortening of OS.

关 键 词：间隙连接蛋白45 结直肠癌 病理特征 预后 

分 类 号：R735.34[医药卫生—肿瘤]