周期性肢体运动障碍患者快速眼球运动密度特征分析  

Rapid eye movement density characteristics in patients with periodic limb movement disorder

作　　者：范滕滕 郭丹 陈洁 张杨[1] 邵岩 于周龙 FAN Teng-teng;GUO Dan;CHEN Jie;ZHANG Yang;SHAO Yan;YU Zhou-long(Peking University Sixth Hospital,Peking Universiy Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Bejing 100191,China)

机构地区：[1]北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191

出　　处：《中国药物依赖性杂志》2022年第4期280-284,共5页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(81901345)。

摘　　要：目的 分析周期性肢体运动障碍患者(periodic limb movement disorder, PLMD)快速眼球运动密度(rapid eye movement density, REMd)的特点,探讨REMd作为辅助诊断PLMD生物标志物的可能性。方法 回顾分析以入睡困难、白天过度嗜睡等为主诉的住院且完成整夜多导睡眠监测(nocturnal polysomnography, nPSG)患者44例。以临床诊断为周期性肢体运动障碍以及周期性肢体运动指数(periodic limb movements index, PLMI)> 15次/h为周期性肢体运动障碍组(28例),其他为对照组(16例)。分别对两组患者人口学资料以及nPSG各项指标进行比较。结果 与对照组相比,PLMD组睡眠效率降低,PLMI增加,REM睡眠比例减少,第1、2、3个REM片段中REMd均增加,平均REMd增加。结论 周期性肢体运动患者REMd显著增加,并且在REM睡眠的前3个周期表现最为显著,提示REMd可能作为PLMD诊断的一个生物标志物。Objective To compare the characteristics of rapid eye movement density(REMd) in patients with periodic limb movement disorder(PLMD) and control group, and to explore the possibility of REMd being used as a biomarker for the diagnosis of PLMD. Methods Nocturnal polysomnography(nPSG) data were colleted and retrospectively analyzed among hospitalized patients with PLMD as a major complaint(n=44). Patients with clinical diagnosis and periodic limb movements index(PLMI)>15 events/h were divided into PLMD group(n=28), and others PLMI ≤ 15 were divided into control group(n=16). Demographic data and nPSG data were compared in PLMD group and control group. Results The PLMD group had significantly lower sleep efficiency, higher PLMI, lower REM(%), higher REMd in 1, 2, 3episode and higher REMd in total sleep time compared with control group. Conclusion Our findings showed that increased REMd might be used as a biomarker of auxiliary diagnosis for PLMD.

关 键 词：周期性肢体运动障碍 快速眼球运动密度 多导睡眠监测 生物标志物 

分 类 号：R749[医药卫生—神经病学与精神病学]