肠道菌群对儿童急性白血病影响的研究进展  

Advances in effects of intestinal microbiota on childhood acute leukemia

作　　者：罗雨希(综述) 刘丽(审校)[2] LUO Yu-xi;LIU Li(the First Clinical Medical College,Capital Medical University,Beijing 100053,China;School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学第一临床医学院,北京100053 [2]首都医科大学基础医学院,北京100069

出　　处：《医学研究生学报》2022年第9期1004-1008,共5页Journal of Medical Postgraduates

摘　　要：肠道菌群是人体最大最复杂的微生态群落系统,肠道中的数万亿微生物因其对宿主病理生理学等多方面的复杂影响,引起了人们的广泛关注。近年来研究发现,肠道菌群通过多种机制影响儿童急性白血病(AL)的发生,并与其治疗、预后及预防均有着密切的关系。文章就肠道菌群紊乱在儿童AL的发生中所起的作用及其对化疗、异基因造血干细胞移植的疗效及预后的影响及相关机制进行综述,旨在为儿童AL的治疗和预防提供新思路。Intestinal microbiota is the largest and most complex micro-ecological community system of human body. Trillions of microorganisms in the intestine have attracted widespread attention because of their complex effects on numerous aspects of host pathophysiology. In recent years, intestinal microbiota has been demonstrated to affect the occurrence of childhood acute leukemia(AL) through multiple mechanisms, which has significant implications for the prevention, treatment and prognosis of AL. In this review, we provided the latest progress in the role of intestinal flora disorder in the development of childhood Al, its influence on the efficacy and prognosis of chemotherapy and allogeneic hematopoietic stem cell transplantation, and its possible mechanisms, which may provide new strategies for the prevention and treatment for childhood AL.

关 键 词：肠道菌群 儿童急性白血病 作用机制 治疗 预防 

分 类 号：R557[医药卫生—血液循环系统疾病]