纤维粘连蛋白在后发性白内障纤维化进展中的作用研究现状  

Current status of research on the role of fibronectin in the progression of posterior capsular opacification fibrosis

作　　者：许文皓 林淑华 贾寓洁 赵健 贾法力 曹婉莹 姜丽兰 李英俊 Wen-Hao Xu;Shu-Hua Lin;Yu-Jie Jia;Jian Zhao;Fa-Li Jia;Wan-Ying Cao;Li-Lan Jiang;Ying-Jun Li(Department of Ophthalmology,the Affiliated Hospital of Yanbian University,Yanji 133000,Jilin Province,China;Department of Ophthalmology,Fuyang People's Hospital,Fuyang 236000,Anhui Province,China)

机构地区：[1]延边大学附属医院眼科,吉林省延吉市133000 [2]中国安徽省阜阳市人民医院眼科,236000

出　　处：《国际眼科杂志》2022年第10期1630-1633,共4页International Eye Science

基　　金：国家自然科学基金项目(No.81960182)。

摘　　要：后发性白内障(PCO)是白内障手术后遗留的晶状体上皮细胞(LECs)发生上皮-间质转化(EMT),产生不透明的瘢痕组织,是白内障手术的主要并发症之一。白内障术后遗留的LECs产生的大量纤维粘连蛋白(FN)与多种细胞表面受体、基质成分和生长因子结合,调节细胞行为。本文旨在回顾有关PCO以纤维粘连蛋白为靶点治疗的文献,并为PCO的临床治疗提供参考。现将近年来纤维粘连蛋白在PCO中的研究现状予以综述。Posterior cataract opacification(PCO) is the epithelial-mesenchymal transformation(EMT) of residual lens epithelial cells(LECs) after cataract surgery, resulting in opaque scar which is one of the main complications of cataract surgery. A large amount of fibronectin(FN) produced by LECs after cataract surgery binds to a variety of cell surface receptors, matrix components and growth factors to regulate cell behavior. The purpose of this article is to review the literatures on the treatment of PCO targeting fibronectin and provide references for clinical treatment of PCO. In this paper, the research status of fibronectin in PCO in recent years is reviewed.

关 键 词：后发性白内障 纤维粘连蛋白 晶状体上皮细胞 纤维化 细胞外基质 

分 类 号：R776.1[医药卫生—眼科]