动脉自旋标记成像在轻度认知功能障碍研究中的应用进展  

Research progresses of arterial spin labeling in mild cognitive impairment

作　　者：孙文昊 孙艳[1] 张楠[1] Wenhao SUN;Yan SUN;Nan ZHANG(Department of Neurology,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院神经内科,天津300052

出　　处：《阿尔茨海默病及相关病杂志》2022年第3期233-236,241,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)的前驱期常常出现轻度认知障碍,轻度认知功能障碍患者存在脑灌注异常,脑灌注异常可能是阿尔茨海默病发生的始动因素之一。动脉自旋标记成像因为无创、重复性好等优势,越来越多的应用于轻度认知功能障碍的脑灌注研究。本文对近年来动脉自旋标记成像在轻度认知功能障碍的诊断、转化和危险因素等研究中的应用作一概述。In prodromal stage of Alzheimer's disease,patients often suffer mild cognitive impairment.Patients with mild cognitive impairment have abnormality in brain cerebral perfusion,which may be one of the initial factors of Alzheimer's disease.Due to its noninvasiveness and repeatability,arterial spin labeling imaging has been used more and more in the study of cerebral perfusion in mild cognitive impairment.This article reviews the application of arterial spin labeling imaging in the diagnosis,transformation and risk factors of mild cognitive impairment in recent years.

关 键 词：轻度认知功能障碍 磁共振成像 动脉自旋标记成像 

分 类 号：R749.16[医药卫生—神经病学与精神病学]