高频深部热疗联合GP化疗方案治疗晚期卵巢癌合并腹腔积液的效果观察  

Curative effect of high-frequency deep hyperthermia combined with GP chemotherapy on advanced ovarian cancer combined with ascites

作　　者：莫丽钦 丁玲玉 刘雅娟[1] 张珍[1] MO Liqin;DING Lingyu;LIU Yajuan(Department of Internal Medicine,Hangzhou Cancer Hospital,Hangzhou 310002,China)

机构地区：[1]杭州市肿瘤医院内三科,浙江杭州310002

出　　处：《全科医学临床与教育》2022年第9期783-787,共5页Clinical Education of General Practice

基　　金：浙江省医药卫生科技计划项目(2019PY064)。

摘　　要：目的观察高频深部热疗联合吉西他滨+顺铂(GP)化疗方案治疗晚期卵巢癌合并腹腔积液的效果。方法选取63例晚期卵巢癌合并腹腔积液患者,随机分为观察组(32例)和对照组(31例)。两组患者均接受腹腔引流术,术后对照组予单纯GP腹腔化疗,观察组在对照组的基础上联合高频深部热疗,均持续4个疗程治疗。观察两组患者近期疗效及腹腔积液控制情况;检测血清及腹水癌胚抗原(CEA)、糖类抗原125(CA125)及糖类抗原153(CA153)水平;采用卡氏功能状态评分(KPS)评估患者生活质量变化;记录两组患者在治疗期间的毒副反应发生情况。结果观察组总有效率及疾病控制率分别为81.25%、96.88%,明显高于对照组的58.06%、80.65%(χ2分别=4.02、4.20,P均<0.05);观察组腹腔积液控制有效率为93.75%,明显高于对照组的74.19%(χ2=4.51,P<0.05)。治疗后,观察组血清及腹水CEA、CA125及CA153水平均较对照组低(t分别=3.91、2.83、4.09;4.34、3.34、2.66,P均<0.05);观察组KPS评分较对照组高(t=3.71,P<0.05)。观察组患者总毒副反应发生率为31.25%,与对照组的29.03%比较,差异无统计学意义(χ2=0.04,P>0.05)。观察组患者有2例患者出现皮肤烫伤情况,及时予以冷敷等治疗,均在1周内恢复。结论腹腔高频深度热疗联合GP腹腔灌注化疗方案可有效下调血清肿瘤标志物的水平,提高晚期卵巢癌合并腹腔积液患者的近期疗效及腹腔积液控制率,改善患者生活质量,且安全性较好。Objective To observe the curative effect of high-frequency deep hyperthermia combined with gemcitabine+cisplatin(GP)chemotherapy on advanced ovarian cancer combined with ascites.Methods A total of 63 patients with advanced ovarian cancer combined with ascites admitted to the hospital were enrolled and randomly divided into observa-tion group(32 cases)and control group(31 cases).Both groups underwent abdominal drainage.After that,control group was given GP intraperitoneal chemotherapy,while observation group was given high-frequency deep hyperthermia on basis of control group.All were continuously treated for 4 courses(2 weeks as a course).The short-term curative effect and as-cites control in both groups were observed.Before and after treatment,samples of fasting venous blood and ascites were collected to detect levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate anti-gen 153(CA153)in serum and ascites.The changes in quality of life were evaluated by Karnofsky performance status(KPS).The occurrence of side effects in both groups during treatment was recorded.Results The total response rate and disease control rate in observation group were 81.25%and 96.88%,which were higher than those in control group(58.06%,80.65%)(χ2=4.02,4.20,P<0.05).The total response rate of ascites control in observation group was signif-icantly higher than that in control group(93.75%vs 74.19%)(χ2=4.51,P<0.05).After treatment,levels of CEA,CA125 and CA153 in serum and ascites in observation group were lower than those in control group(t=3.91,2.83,4.09,4.34,3.34,2.66,P<0.05),and KPS score was higher than that in control group(t=3.71,P<0.05).There was no significant difference in the total incidence of side effects between observation group and control group(31.25%vs 29.03%)(χ2=0.04,P>0.05).In observation group,there were 2 cases with skin scalds,who were recovered within 1 week after cold compress.Conclusion Intraperitoneal high-frequency deep hyperthermia combined with GP intraperitoneal infusion chem

关 键 词：晚期卵巢癌 腹腔积液 高频深部热疗 腹腔化疗 

分 类 号：R737.31[医药卫生—肿瘤]