A smart nanoprobe based on luminescent terbium metal-organic framework coated gold nanorods for monitoring and photo-stimulated combined thermal-chemotherapy  

作　　者：Tong Zhang Liying Qin Liangliang Liu Meina Zhang Tianyi Du Yifan Fan Huicheng Yan Pingru Su Ping Zhou Yu Tang 

机构地区：[1]Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China [2]School/Hospital of Stomatology,Lanzhou University,Lanzhou 730000,China

出　　处：《Journal of Rare Earths》2022年第9期1371-1381,I0002,共12页稀土学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(21871121);Science and Technological Plan of Gansu Province(20YF3GA012);the 111 Project(B20027)。

摘　　要：Real-time monitoring and accurate treatment are of great significance for reducing the side effects during the cancer therapy.In this work,we rationally prepared a smart nanoprobe based on core-shell terbium metal-organic gramework(MOF)with highly effective photothermal conversion capacity and drug release efficiency under near-infrared light irradiation for real-time fluorescence imaging-guided multimodal therapy.The nanoprobe can achieve prominent photothermal therapy and controllable drug release,act as a fluorescence thermometer,and also real-time feedback of temperature is expected to be achieved.At the same time,the two-photon ligand design significantly improves the tissue penetration ability of the nanoprobe.Our work is expected to provide a reference for precise treatment and real-time monitoring of tumors and at the same time provide new ideas for the formulation of individualized treatment plans.

关 键 词：Lanthanide metal-organic frameworks(LnMOFs) Fluorescence thermometer Two-photon ligand Photothermal therapy CHEMOTHERAPY Rare earths 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]