氨磺必利与氯氮平治疗阴性症状为主精神分裂症的疗效分析  

Analysis of the Efficacy of Amisulpride and Clozapine in the Treatment of Schizophrenia with Negative Symptoms

作　　者：孙丽 SUN Li(Liaoning Province Demobilized Soldiers Kangning Hospital,Xingcheng 125100,China)

机构地区：[1]辽宁省复员军人康宁医院,辽宁兴城125100

出　　处：《中国医药指南》2022年第27期97-99,共3页Guide of China Medicine

摘　　要：目的 针对氨磺必利以及氯氮平两种药物对阴性症状为主精神分裂患者的治疗效果进行研究。方法 将本院于2021年1月至2022年1月所收治的90例以阴性症状为主的精神分裂症患者作为研究对象,遵循随机分配的原则,将其分为观察组与对照组,每组各45例患者,其中的对照组采用氯氮平药物进行治疗,而观察组则采用氨磺必利药物治疗,最后对两组患者的治疗效果、不良反应状况、生活质量评分和治疗前后的阴性症状进行对比。结果 两组患者的治疗有效率数据差异较小,无统计学意义(P> 0.05)。但两组患者的不良反应状况存在一定的差异,其中观察组患者的不良反应发生率为11.11%,对照组的不良反应率为26.67%,有统计学意义(P <0.05)。对于两组患者生活质量评分的对比显示,观察组患者的生活质量评分优于对照组,具有统计学意义(P <0.05)。而在治疗后两组患者的阴性症状均有所改善,但观察组患者的评分状况更为良好,有统计学意义(P <0.05)。结论 两种药物对于治疗阴性症状为主的精神分裂患者均具有良好的疗效,而不良反应状况存在一定的差异,其中采用氨磺必利进行治疗的患者不良反应状况较低。同时,该组生活质量和阴性症状的改善率也相对较高,更具使用安全性,建议在临床治疗中加大对其的推广力度。Objective To investigate the therapeutic effects of amisulpride and clozapine on patients with schizophrenia with negative symptoms.Methods Taking 90 patients with schizophrenia, mainly negative symptoms, admitted to our hospital from January 2021 to January 2022 as the research object, following the principle of random allocation, they were divided into an observation group and a control group. 45 patients in each group. The control group was treated with clozapine drugs, the observation group was treated with amisulpride drugs, and finally the treatment effect, adverse reaction status, quality of life score and before and after treatment of the two groups of patients The negative symptoms are compared.Results The difference in the treatment efficiency data between the two groups of patients was small and not statistically significant(P>0.05).However, there was a certain difference in the adverse reaction status between the two groups. The incidence of adverse reactions in the observation group was 11.11%, and the incidence of adverse reactions in the control group was 26.67%, which was statistically significant(P<0.05). The comparison of the quality of life scores of the two groups of patients showed that the quality of life scores of the observation group were better than the control group, which was statistically significant(P<0.05). The negative symptoms of the two groups of patients improved after treatment, but the observation group’s scoring condition was better and statistically significant(P<0.05). Conclusion The two drugs have a good effect on the treatment of schizophrenic patients with negative symptoms, and there are certain differences in adverse reaction status. Among them, the group of patients treated with amisulpride has lower adverse reaction status. At the same time, the improvement rate of quality of life and negative symptoms is relatively high, and it is safer to use. It is recommended to increase its promotion in clinical treatment.

关 键 词：氯氮平 氨磺必利 阴性症状 精神分裂症 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]