丁苯酞对心源性脑梗死患者神经功能及血管内皮生长因子的影响  

Effects of butylphthalide on neurological function and vascular endothelial growth factor in patients with cardiogenic cerebral infarction

作　　者：朱亚兰[1] 吴湘军[1] 郑海燕[1] Zhu Ya-lan;Wu Xiang-jun;Zheng Hai-yan(Department of Neurology,Guanghan People's Hospital,Guanghan 618300,Sichuan,China)

机构地区：[1]广汉市人民医院神经内科,四川广汉618300

出　　处：《四川生理科学杂志》2022年第9期1513-1516,共4页Sichuan Journal of Physiological Sciences

基　　金：广汉市经济信息化和科学技术局项目(编号:GH2019FS09)。

摘　　要：目的:研究丁苯酞(Butylphthalide,NBP)对心源性脑梗死患者神经功能及血管内皮生长因子的影响。方法:选取2019年6月到2021年8月我院收治172例心源性脑梗死患者,采用随机数字表法分为NBP治疗组与对照组,各86例。对照组采取常规治疗,NBP治疗组在对照组基础上加用NBP静脉滴注(100 mL,Bid),疗程持续14 d。分别于治疗前及治疗后次日采用美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评估神经功能缺损情况;分别于治疗前及治疗后次日采用酶联免疫吸附法测定血管内皮生长因子(Vascular endothelial growth factor,VEGF)、B型利钠肽(B-type Natriuretic Peptide,BNP)水平;采用凝结法测定血浆纤维蛋白原(Plasma fibrinogen,Fbg)水平并比较其差异;随访患者3 m,对比两组患者急性期及治疗后3 m内病死率,发病后3 m采用脑卒中评估量表(Modified Rankin Scale,mRS)评估患者生活能力,比较两组患者治疗期间的药物不良反应发生率。结果:与治疗前相比,治疗后两组BNP、Fbg、NIHSS评分均明显降低(P<0.05),其中NBP治疗组更为显著(P<0.05);与治疗前相比,两组VEGF水平均明显增加(P<0.05),其中NBP治疗组更为显著(P<0.05);治疗后3 m,NBP治疗组患者回访病死率、mRS评分明显低于对照组(P<0.05);两组药物不良反应发生率比较无统计学差异(P<0.05)。结论:NBP治疗心源性脑梗死能显著提升患者神经功能及VEGF水平,促进患者预后恢复并提高生存质量,值得临床推广。Objective:To study the effect of Butylphthalide(NBP)on neurological function and vascular endothelial growth factor in patients with cardiogenic cerebral infarction.Methods:A total of 172 patients with cardiogenic cerebral infarction admitted to our hospital from June 2019 to August 2021 were selected and divided into NBP treatment group and control group by random number table method,with 86 cases in each group.The patients in control group received conventional treatment,while the patients in NBP treatment group received NBP intravenous drip(100 mL,Bid)on the basis of the control group,and the course of treatment lasted 14 days.Before treatment and the next day after treatment,the National Institute of Health Stroke Scale(NIHSS)was used to evaluate neurological deficit;ELISA was used to measure vascular endothelial growth factor(VEGF),B-type natriuretic peptide(BNP)levels.Also,the plasma fibrinogen(Fbg)level was measured by coagulation method and their differences were compared;follow�up 3 m,the mortality rates in the acute phase and within 3 m after treatment were compared between the two groups.Three months after the onset of stroke,the Modified Rankin Scale(mRS)was used to evaluate the ability to live,and the incidence of adverse drug reactions in the two groups during treatment was evaluated.Results:Compared with before treatment,the BNP,Fbg and NIHSS scores of the two groups were significantly decreased(P<0.05),and the NBP treatment group was more significant(P<0.05).Three months after treatment,the mortality rate and mRS score of the NBP treatment group was significantly lower than that of the control group(P<0.05);there was no significant difference in the incidence of adverse drug reactions between the two groups(P<0.05).Conclusion:NBP treatment of cardiogenic cerebral infarction can significantly improve the neurological function and VEGF level of patients,and can promote the recovery of patients'prognosis and improve the quality of life,which is worthy of clinical promotion.

关 键 词：丁苯酞 心源性脑梗死 血管内皮生长因子 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]