IL-6和动脉粥样硬化性缺血性卒中的关系研究进展  

Advances in the Relationship between IL-6 and Atherosclerotic Ischemic Stroke

作　　者：龚宇田 黎洁洁[1] GONG Yutian;LI Jiejie(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心,北京100070

出　　处：《中国卒中杂志》2022年第9期1022-1026,共5页Chinese Journal of Stroke

摘　　要：缺血性卒中是一种病因复杂的综合征,其中动脉粥样硬化是主要病因之一。流行病学、分子生物学证据表明IL-6促进动脉粥样硬化斑块的形成和生长,影响缺血性卒中的发生、发展及预后。新近的临床研究进一步证实干预IL-6通路有望成为缺血性卒中治疗的新靶点。本综述从分子生物学、流行病学和新近开展的临床研究阐述IL-6在缺血性卒中发生、预后中的作用,以及作为潜在治疗靶点的可能性。Ischemic stroke is a complex syndrome,and atherosclerosis is one of the main causes.Interleukin 6(IL-6)is an important inflammatory factor involved in atherosclerosis.The epidemiological and molecular biological evidence indicated that IL-6 can promote the formation and growth of atherosclerosis plaque and influence the occurrence,development and prognosis of ischemic stroke.Recent clinical studies further suggested IL-6 may be a potential therapeutic target of ischemic stroke.This review aimed to elaborate the role of IL-6 in the occurrence and prognosis of ischemic stroke from the perspectives of molecular mechanism,epidemiology and clinical research.

关 键 词：缺血性卒中 动脉粥样硬化 白介素-6 炎症 心血管疾病 

分 类 号：R743.3[医药卫生—神经病学与精神病学]