The regulatory variant rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of endothelin receptor type A  

作　　者：Di Luan Xing-Lun Dang Xi Chen Zi-Xu Wang Shi-Fei Ye Yuan-Xiang Zhang Li-Li Yuan Kun Lian 

机构地区：[1]School of Medicine,Southeast University,Nanjing,Jiangsu 210009,China [2]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [3]Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,China [4]Department of Neurosurgery,The Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101,China [5]Department of geriatric psychiatry,Nanjing Brain Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu 210024,China [6]Department of Cerebrovascular Disease,Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine,Shanghai 200000,China [7]School of Pharmacy,Wannan Medical College,Wuhu,Anhui 241000,China [8]Department of Neurology,First Affiliated Hospital of Wannan Medical College,Wuhu,Anhui 241000,China [9]Yunnan Clinical Research Center for Mental Disorders,the first Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650032,China

出　　处：《Life Research》2022年第4期27-35,共9页TMR生命研究

摘　　要：Genome-wide association studies have found that rs17612742 increases the risk of large artery atherosclerotic stroke.The rs17612742 was located in the intron region of Endothelin receptor type A(NRA),which was cellular and gender-heterogeneous.Functional genomics studies of rs17612742 were carried out through some public databases,and it was found that rs17612742 was located in the chromatin open region and promoted the expression of NRA.Compared with the control group,EDNRA expression increased in middle cerebral artery occlusion exposed rodents.However,age heterogeneity of EDNRA expression under physiological and pathological conditions was not observed.In addition,we also discussed how to conduct further empirical studies to provide evidence that rs17612742 confers the risk of large artery atherosclerotic stroke by increasing the expression of NRA.

关 键 词：large artery atherosclerotic stroke rs17612742 EDNRA 

分 类 号：R73[医药卫生—肿瘤]