血清肝细胞生长因子联合多中心卒中调查预测模型与栓后出血评分模型量表对急性缺血性脑卒中患者静脉溶栓后出血转化风险的预测价值分析  

Analysis of the predictive value of serum HPF combined with MSS and HAT models on the risk of hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke

作　　者：肖悠美[1] 孙晓静[1] 王爱丽[1] XIAO You-mei;SUN Xiao-jing;WANG Ai-li(Department of Neurology,Zhengzhou People′s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州人民医院神经内科,河南郑州450000

出　　处：《实用医院临床杂志》2022年第5期107-110,共4页Practical Journal of Clinical Medicine

摘　　要：目的 探讨血清肝细胞生长因子(HGF)联合多中心卒中调查预测模型(MSS)与栓后出血评分(HAT)对急性缺血性脑卒中(AIS)患者静脉溶栓后出血转化风险的预测价值。方法 我院收治的166例AIS患者,根据静脉溶栓治疗后有无出血性转化分为出血性转化组32例与非出血性转化组134例。比较两组溶栓前后HGF水平及溶栓前MSS、HAT评分,分析影响AIS患者静脉溶栓后出血转化风险的相关因素,分析HGF、MSS、HAT联合预测AIS患者发生出血性转化的临床价值。结果 治疗后,两组HGF水平均下降(P<0.05);治疗前后出血性转化组HGF水平、MSS及HAT评分均高于非出血性转化组(P<0.05)。年龄、后循环梗死、溶栓后HGF水平、MSS评分、HAT评分为影响AIS患者静脉溶栓后发生出血转化风险的独立危险因素(P<0.05)。联合HGF、MSS、HAT预测AIS患者发生出血性转化的灵敏度、特异度、AUC分别为89.45%、91.56%、0.993,均高于单一检测(P<0.05)。结论 临床可通过加强HGF、MSS、HAT检测,可快速、准确评估AIS患者静脉溶栓后发生出血转化风险,联合三者检测在预测静脉溶栓后发生出血转化风险方面具有良好的应用价值。Objective To explore the value of serum hepatocyte growth factor(HGF) combined with multicenter stoker survey(MSS) model and hemorrhage after thrombolysis(HAT) model in the prediction of the risk of hemorrhagic transformation in patients with acute ischemic stroke(AIS) after intravenous thrombolysis.Methods One hundred and sixty-six patients with AIS admitted to our hospital were selected. According to presence or absence of hemorrhagic transformation after intravenous thrombolysis, the patients were divided into a hemorrhagic transformation group(n=32) and a non-hemorrhagic transformation group(n=134). The HGF level before and after thrombolysis and the MSS and HAT scores before and after thrombolysis were compared between the two groups. Logistic regression was used to analyze the related factors that affecting the risk of hemorrhagic transformation in the AIS patients after intravenous thrombolysis. ROC curve analysis was used to analyze the sensitivity and the specificity of the combination of HGF, MSS and HAT in predicting hemorrhagic transformation in the AIS patients.Results After treatment, HGF levels were decreased in the two groups(P<0.05). The HGF level and MSS and HAT scores in the hemorrhagic transformation group before and after treatment were higher than those in the non-hemorrhagic transformation group(P<0.05). The Logistic regression analysis showed that age, posterior circulation infarction, HGF level after thrombolysis, MSS score, and HAT score were independent risk factors that affecting hemorrhagic transformation after intravenous thrombolysis in the AIS patients(P<0.05). The ROC curve analysis showed that the sensitivity, specificity, and AUC of the combination of HGF, MSS and HAT were 89.45%, 91.56%, and 0.993, respectively which were significantly higher than those of the single index(P<0.05).Conclusion In clinical practice, the detection of HGF, MSS, and HAT can be strengthened to quickly and accurately assess the risk of hemorrhagic transformation in AIS patients after intravenous thromb

关 键 词：血清肝细胞生长因子 多中心卒中调查预测模型 栓后出血评分 急性缺血性脑卒中 静脉溶栓后出血转化风险 预测价值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]