奥拉帕利联合TP化疗方案对晚期卵巢癌患者血清血管形成因子和细胞凋亡因子的影响  

Impact of olaparib combined with TP chemotherapy regimen on serum angiogenic factors and apoptosis factors in patients with advanced ovarian cancer

作　　者：蔡志芳 沈晓青 王丽 CAI Zhifang;SHEN Xiaoqing;WANG Li(Department of Gynecology,Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院妇科,上海200090

出　　处：《检验医学与临床》2022年第19期2656-2659,2663,共5页Laboratory Medicine and Clinic

摘　　要：目的观察奥拉帕利联合TP化疗方案(紫杉醇+顺铂)对晚期卵巢癌的疗效,及其对血管形成因子和细胞凋亡因子的影响。方法选择2018年1月至2020年12月该院收治的晚期卵巢癌患者90例为研究对象,根据随机数字表法将患者分为观察组和对照组,每组45例。对照组采用TP化疗方案,观察组在对照组的基础上予以奥拉帕利治疗。观察两组治疗后的疗效及不良反应,两组治疗前后血清人附睾蛋白4(HE4)、转铁蛋白(SF)、糖类抗原(CA)125、CA199、基质细胞衍生因子-1α(SDF-1α)、基质金属蛋白酶-9(MMP-9)、血管生成素-2(Ang-2)、B淋巴细胞瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、可溶性细胞凋亡因子(sFas)和Bcl-2结合抗凋亡基因-1(Bag-1)水平的变化。结果观察组的总有效率为80.00%,对照组的总有效率为57.78%,差异有统计学意义(χ^(2)=4.199,P<0.05);两组的不良反应发生率差异无统计学意义(P>0.05)。治疗后,观察组的肿瘤相关指标(HE4、SF、CA125和CA199)和血管生长相关因子(SDF-1α、MMP-9和Ang-2)水平均低于对照组(P<0.05)。治疗后,观察组与对照组sFas、Bcl-2、Bag-1、Bax水平比较,差异有统计学意义(P<0.05)。结论奥拉帕利联合TP化疗方案治疗晚期卵巢癌的疗效显著,与抑制血管形成,促进细胞的凋亡有关。Objective To observe the efficacy of olaparib combined with TP chemotherapy(paclitaxel+cisplatin)on advanced ovarian cancer and its impact on the angiogenic and apoptosis factors.Methods A total of 90 patients with advanced ovarian cancer who were admitted to our hospital from January 2018 to December 2020 were divided into observation group and control group according to the random number method,with 45 cases in each group.The control group was treated with TP chemotherapy,and the observation group was treated with olaparib on the basis of the control group.The efficacy and adverse reactions were observed in the two groups after treatment.The serum human epididymal protein 4(HE4),transferrin(SF),carbohydrate antigen(CA)125,CA199,stromal cell-derived factor-1α(SDF-1α),matrix metalloproteinase-9(MMP-9),angiopoietin-2(Ang-2),B lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),soluble Fas(sFas)and Bcl-2 binding anti apoptotic gene-1(Bag-1)were compared in two groups before and after treatment.Results The total effective rate was 80.00%in the observation group,which was significantly better than 57.78%in the control group(χ^(2)=4.199,P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the levels of HE4,SF,CA125 and CA199 and SDF-1α,MMP-9 and Ang-2 in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of sFas,Bcl-2,Bag-1 and Bax between the two groups had statistical significance(P<0.05).Conclusion The efficacy of olaparib combined with TP chemotherapy on advanced ovarian cancer is obvious,which is related to inhibiting blood vessel formation and promoting cell apoptosis.

关 键 词：晚期卵巢癌 奥拉帕利 血管生成 细胞凋亡 化疗 

分 类 号：R737.31[医药卫生—肿瘤]