精神分裂症共病高血压患者认知功能影响因素的研究  

Study on the influencing factors of cognitive function in schizophrenia patients with hypertensive comorbidity

作　　者：魏辰 肖鹏 张秋雨 田博[4] Wei Chen;Xiao Peng;Zhang Qiuyu;Tian Bo(Medical Department of Qingdao University,Qingdao 266071,China;Spiritual Department of Shandong Daizhuang Hospital,Ji'ning 272000,China;School of Mental Health,Ji'ning Medical College,Ji'ning 272067,China;Children Department,Qingdao Mental Health Center,Qingdao 366340,China,China)

机构地区：[1]青岛大学医学部,266071 [2]山东省戴庄医院精神科,济宁272000 [3]济宁医学院精神卫生学院,272067 [4]青岛市精神卫生中心儿少科,366340

出　　处：《神经疾病与精神卫生》2022年第9期641-646,共6页Journal of Neuroscience and Mental Health

基　　金：济宁市科技发展计划项目(2020YXNS042)。

摘　　要：目的探讨精神分裂症共病高血压患者认知功能缺损的特征及影响因素。方法选取2020年12月至2021年8月在山东省戴庄医院住院且病情稳定的130例精神分裂症患者作为研究对象,分为共病高血压组(n=64)和非共病高血压组(n=66)。比较两组患者一般人口学及临床资料、重复性成套神经心理状态测验(RBANS)评分。采用Spearman相关分析精神分裂症患者认知功能与一般人口学及临床资料、共病高血压的相关性。采用多重线性回归分析精神分裂症患者认知功能的影响因素。结果共病高血压组患者较非共病高血压组患者精神分裂症病程长、体重重、体重指数高、颅脑CT异常者多,差异有统计学意义(P<0.05)。共病高血压组患者RBANS延迟记忆维度评分低于非共病高血压组[(60.88±16.76)分比(68.76±15.97)分],差异有统计学意义(t=-2.746,P=0.007)。延迟记忆维度评分与共病高血压呈负相关(r=-0.252,P<0.05)。多重线性回归分析结果显示,受教育年限是RBANS总分及即刻记忆、空间结构、语言、注意、延迟记忆维度评分的影响因素(β=7.363、1.297、1.479、1.575、2.123、1.317;P<0.05);精神分裂症病程是即刻记忆、延迟记忆维度评分的影响因素(β=-0.300、-0.303;P<0.05);精神分裂症家族史是空间结构维度评分的影响因素(β=-7.015,P<0.05);颅脑CT表现是语言维度评分的影响因素(β=-2.759,P<0.05);共病高血压是延迟记忆维度评分的影响因素(β=-6.950,P<0.05)。结论稳定期的高血压影响精神分裂症患者的部分认知功能,精神分裂症病程、受教育年限、家族史和颅脑CT异常可能是精神分裂症患者认知受损的影响因素。Objective To investigate the characteristics and influencing factors of cognitive deficit in schizophrenia patients with hypertensive comorbidity.Methods From December 2020 to August 2021,a total of 130 cases of stable schizophrenia patients in the inpatient department of Shandong Daizhuang Hospital were recruited as the research object,and divided into comorbid hypertension group(n=64) and non-comorbid hypertension group(n=66).The general demographic and clinical data as well as the scores of Repeatable Battery for the Assessment of Neuropsychological Status(RBANS) were compared between the two groups.Spearman correlation was used to analyze the correlation between cognitive function of schizophrenic patients and general demographic,clinical data and comorbid hypertension.Multiple linear regression was used to analyze the influencing factors of cognitive function in schizophrenic patients.Results Compared with the non-comorbid hypertension group,the patients in the comorbid hypertension group had a longer course of schizophrenia,a larger body weight,a higher body mass index,and more brain CT abnormalities,and the differences were statistically significant(P <0.05).RBANS delayed memory score in the comorbid hypertension group was lower than that in the non-comorbid hypertension group [(60.88±16.76) vs(68.76±15.97)],and the difference was statistically significant(t=-2.746,P=0.007).The score of delayed memory was negatively correlated with comorbid hypertension(r=-0.252,P <0.05).The results of multiple linear regression analysis showed that the number of years of education was the influencing factor of RBANS total score and immediate memory,visuospatial,language,attention and delayed memory(β=7.363,1.297,1.479,1.575,2.123,1.317;P <0.05).The course of schizophrenia was the influencing factor of immediate memory and delayed memory(β=-0.300,-0.303;P <0.05).Family history of schizophrenia was the influencing factor of visuospatial dimension(β=-7.015,P <0.05).Brain CT abnormalities was the influencing factor of la

关 键 词：精神分裂症 高血压 认知功能 影响因素 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]