FGF、IGF1R、CD147在急性脑梗死患者中的表达及其与颈动脉狭窄程度的相关性  

Expression of FGF,IGF1R and CD147 in patients with acute cerebral infarction and their correlation with the degree of carotid artery stenosis

作　　者：吕志坤[1] 魏萌萌 李国珍[1] 张晓红[2] 卢波[1] 沈丹平[3] 贾磊华 王沙沙[1] LYU Zhikun;WEI Mengmeng;LI Guozhen;ZHANG Xiaohong;LU Bo;SHEN Danping;JIA Leihua;WANG Shasha(the Second Department of Neurology,the Second Central Hospital of Baoding,Baoding,Hebei 072750,China;the First Department of Neurology,the Second Central Hospital of Baoding,Baoding,Hebei 072750,China;CT Room,the Second Central Hospital of Baoding,Baoding,Hebei 072750,China)

机构地区：[1]河北省保定市第二中心医院神经内二科,河北保定072750 [2]河北省保定市第二中心医院神经内一科,河北保定072750 [3]河北省保定市第二中心医院CT室,河北保定072750

出　　处：《国际检验医学杂志》2022年第19期2342-2345,共4页International Journal of Laboratory Medicine

基　　金：河北省科技计划项目(17277711D);保定市科技局课题立项(2141ZF025)。

摘　　要：目的 探讨成纤维细胞生长因子(FGF)、胰岛素样生长因子1受体(IGF1R)、CD147在急性脑梗死(ACI)患者中的表达及其与颈动脉狭窄程度的相关性。方法 选取2019年1月至2021年5月该院收治的150例ACI患者为ACI组,根据颈动脉狭窄程度分为轻度狭窄组(24例)、中度狭窄组(48例)、重度狭窄组(56例)、完全闭塞组(22例),另选取同期65例体检健康者为对照组。采用酶联免疫吸附试验检测血清FGF、IGF1R、CD147水平,分析ACI患者血清FGF、IGF1R、CD147水平与颈动脉狭窄程度的相关性。结果 与对照组比较,ACI组血清FGF、CD147水平升高(P<0.05),IGF1R水平降低(P<0.05)。轻度狭窄组、中度狭窄组、重度狭窄组、完全闭塞组血清FGF、CD147水平依次升高(P<0.05),IGF1R水平依次降低(P<0.05)。Spearman相关性分析显示,ACI患者血清FGF、CD147水平与颈动脉狭窄程度呈正相关(r=0.526、0.557,P<0.05),IGF1R水平与颈动脉狭窄程度呈负相关(r=-0.603,P<0.05)。结论 ACI患者血清FGF、CD147水平升高,IGF1R水平降低,与颈动脉狭窄程度密切相关,检测血清FGF、IGF1R、CD147水平有利于制订个性化治疗方案。Objective To investigate the expression of fibroblast growth factor(FGF),insulin-like growth factor 1 receptor(IGF1 R) and CD147 in patients with acute cerebral infarction(ACI) and their correlation with the degree of carotid artery stenosis.Methods A total of 150 ACI patients admitted to the hospital from January 2019 to May 2021 were selected as the ACI group.According to the degree of carotid artery stenosis, they were divided into mild stenosis group(24 cases),moderate stenosis group(48 cases),severe stenosis group(56 cases),and complete occlusion group(22 cases).Another 65 healthy people were selected as the control group.Serum levels of FGF,IGF1 R and CD147 were measured by enzyme-linked immunosorbent assay, and the correlation between serum levels of FGF,IGF1 R and CD147 and the degree of carotid artery stenosis in ACI patients was analyzed.Results Compared with the control group, serum levels of FGF and CD147 in ACI group were increased and IGF1 R level was decreased(P<0.05).The serum levels of FGF and CD147 in mild stenosis group, moderate stenosis group, severe stenosis group and complete occlusion group were successively increased(P<0.05),and the levels of IGF1 R were successively decreased(P<0.05).Spearman correlation analysis showed that the levels of serum FGF and CD147 were positively correlated with the degree of carotid artery stenosis in ACI patients(r=0.526、0.557,P<0.05),and the level of IGF1 R was negatively correlated with the degree of carotid artery stenosis(r=-0.603,P<0.05).Conclusion The serum levels of FGF and CD147 are increased and IGF1 R is decreased in patients with ACI,which are closely related to the degree of carotid artery stenosis.The detection of serum levels of FGF,IGF1 R and CD147 is beneficial for the development of personalized treatment.

关 键 词：急性脑梗死 颈动脉狭窄 成纤维细胞生长因子 胰岛素样生长因子1受体 CD147 

分 类 号：R743.3[医药卫生—神经病学与精神病学]