草鱼粉中4种磺胺类药物残留基体标准物质的研制  

Preparation of matrix reference materials for four sulfonamides residues in grass carp powder

作　　者：王新新 封腾望 王慧姣 李晋成[2] 孙慧武[2] 刘欢[2] WANG Xin-xin;FENG Teng-wang;WANG Hui-jiao;LI Jin-cheng;SUN Hui-wu;LIU Huan(College of Fisheries and Life Science,Shanghai Ocean University,Shanghai 201306,China;Chinese Academy of Fishery Sciences,Key Labrotary of Control of Quality and Safety for Aquatic Products,Minisrty of Agriculture and Rural Affairs,Beijing 100141,China)

机构地区：[1]上海海洋大学水产与生命学院,上海201306 [2]中国水产科学研究院,农业农村部水产品质量安全控制重点实验室,北京100141

出　　处：《淡水渔业》2022年第5期96-103,共8页Freshwater Fisheries

基　　金：中国水产研究院基本科研业务费(2020TD75)。

摘　　要：建立草鱼粉中磺胺甲噁唑(Sulfamethoxazole,SMZ)、磺胺二甲异噁唑(Sulfaisoxazole,SFZ)、磺胺二甲基嘧啶(sulfamethazine,SM_(2))、磺胺甲基嘧啶(sulfamerazine,SM 1)药物残留基体标准物质制备方法。以草鱼(Ctenopharyngodon idella)为研制对象,样品经过药浴、均质、冷冻干燥、过筛、包装制备而得。经均匀性、稳定性检验,多家实验室合作定值以及不确定度评估等过程,确定草鱼肌肉粉中SMZ、SFZ、SM_(2)、SM_(1)的量值分别为(22.22±7.75)、(24.04±8.04)、(31.11±5.84)、(28.55±7.18)μg/kg。结果表明,草鱼粉基体标准物质的均匀性良好,稳定性符合标准物质技术要求,定值结果可靠。该方法可为水产品基质中磺胺类药物残留基体标准物质的制备提供技术参考。The preparation method of matrix reference materials for drug residues of sulfamethoxazole(SMZ),sulfaisoxazole(SFZ),sulfamethazine(SM_(2))and sulfamerazine(SM_(1))in grass carp powder was established in this study.The samples of grass carp were prepared by medicine bath,sampling,homogenization,freeze-drying,screening,mixing and packaging.Through the processes of uniformity test,stability test,cooperative setting by multiple laboratories and uncertainty evaluation,the quantities of SMZ,SFZ,SM_(2)and SM_(1)in grass carp powder were finally determined to be(22.22±7.75),(24.04±8.04),(31.11±5.84),(28.55±7.18)μg/kg,respectively.The results showed that the uniformity of grass carp powder matrix reference material was good.The stability meets the technical requirements of reference material,and the setting result was reliable.The method can provide technical reference for preparing sulfonamides residue matrix reference materials in aquatic products matrix.

关 键 词：草鱼粉 磺胺类药物 基体标准物质 样品制备 联合定值 

分 类 号：TS207.3[轻工技术与工程—食品科学]